Biomol Ther.
2022 Nov;30(6):479-489. 10.4062/biomolther.2022.017.
Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance
- Affiliations
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- 1College of Pharmacy, Keimyung University, Daegu 42601, Republic of Korea
- 2Department of Pharmacy, Daegu Catholic University, Gyeongsan 38430, Republic of Korea
- KMID: 2534697
- DOI: http://doi.org/10.4062/biomolther.2022.017
Abstract
- 5-Fluorouracil (5-FU) remains to be an important chemotherapeutic drug for treating several cancers when targeted therapy is unavailable. Chemoresistance limits the clinical utility of 5-FU, and new strategies are required to overcome the resistance. Reactive oxygen species (ROS) and antioxidants are balanced differently in both normal and cancer cells. Modulating ROS can be one method of overcoming 5-FU resistance. This review summarizes selected compounds and endogenous cellular targets modulating ROS generation to overcome 5-FU resistance.
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