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Unravelling Polycystic Ovary Syndrome and Its Comorbidities

Kim KW

Polycystic ovary syndrome (PCOS) is a chronic multisystem endocrine disorder that affects women of reproductive age. In the ovary, the dynamic balance between dormant and growing follicles that culminates in...
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Assessment of Insulin Secretion and Insulin Resistance in Human

Park SY, Gautier JF, Chon S

The impaired insulin secretion and increased insulin resistance (or decreased insulin sensitivity) play a major role in the pathogenesis of all types of diabetes mellitus (DM). It is very important...
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Guidelines on Implementing Antimicrobial Stewardship Programs in Korea

Yoon YK, Kwon KT, Jeong SJ, Moon C, Kim B, Kiem S, Kim Hs, Heo E, Kim SW, KSfATKSoIDaKSoHSP

These guidelines were developed as a part of the 2021 Academic R&D Service Project of the Korea Disease Control and Prevention Agency in response to requests from healthcare professionals in...
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Evolution of Antimicrobial Resistance Levels of ESKAPE Microorganisms in a Peruvian IV-Level Hospital

Flores-Paredes W, Luque N, Albornoz R, Rojas N, Espinoza M, Pons MJ, Ruiz J

Backgound: The members of the so-called ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) are a frequent cause of severe infection, ranking among...
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Core Elements for Successful Implementation of Antimicrobial Stewardship Programs

Hwang S, Kwon KT

Antimicrobial resistance has emerged as a serious global public health threat. One of the countermeasures to increased antibiotic-resistant bacterial infections is the use of an integrative intervention strategy for the...
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The effect of genistein on insulin resistance, inflammatory factors, lipid profile, and histopathologic indices in rats with polycystic ovary syndrome

Amanat S, Ashkar F, Eftekhari MH, Tanideh N, Doaei S, Gholamalizadeh M, Koohpeyma F, Mokhtari M

Objective: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, irregular menstruation, ovulatory dysfunction, and insulin resistance. Recent studies have reported the possible role of phytoestrogens in PCOS. This animal study...
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Colistin resistance and plasmidmediated mcr genes in Escherichia coli and Salmonella isolated from pigs, pig carcass and pork in Thailand, Lao PDR and Cambodia border provinces

Pungpian C, Lee S, Trongjit S, Sinwat N, Angkititrakul S, Prathan R, Srisanga S, Chuanchuen R

Background Colistin and carbapenem-resistant bacteria have emerged and become a serious public health concern, but their epidemiological data is still limited. Objectives This study examined colistin and carbapenem resistance in Escherichia coli and...
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Lurasidone in Therapy of Treatment-resistant Ultra-rapid Cycling Bipolar Disorder: Case Report

Siwek M, Gorostowicz A

Lurasidone is an atypical antipsychotic approved for the treatment of schizophrenia and bipolar depression. It seems to have a favorable metabolic profile and low risk of causing adverse interactions. Here...
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Effect of 2% Chlorhexidine Bathing on the Incidence of Hospital-Acquired Infection and Multidrug-Resistant Organisms in Adult Intensive Care Unit Patients: Systematic Review and Meta-Analysis

Seo J, Song R

  • KMID: 2519546
  • J Korean Acad Nurs.
  • 2021 Aug;51(4):414-429.
Purpose: This systematic review and meta-analysis analyzed the effects of 2% chlorhexidine bathing on the incidence of hospital-acquired infection (HAI) and multidrug-resistant organisms (MDRO) in adult intensive care units. Methods:...
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Increased Risk of Nonalcoholic Fatty Liver Disease in Individuals with High Weight Variability

Jung I, Koo DJ, Lee MY, Moon SJ, Kwon H, Park SE, Rhee EJ, Lee WY

Background: Weight loss through lifestyle modification is recommended for patients with nonalcoholic fatty liver disease (NAFLD). Recent studies have suggested that repeated loss and gain of weight is associated with...
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The Impact of Antibiotic Burden on the Selective Resistance of Gram Negative Bacteria in Children

Park S, Lee E, So HJ, Yoo RN, Lee J

Background: The purpose of this study was to investigate the association between antibiotic use and the antimicrobial resistance of gram-negative bacteria isolated from blood cultures in a pediatric population. Methods: From...
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Identification and infection control of carbapenem-resistant Enterobacterales in intensive care units

Yi J, Kim KH

Infections with multidrug-resistant organisms among patients in intensive care units (ICUs) are associated with high mortality. Among multidrug-resistant organisms, carbapenem-resistant Enterobacterales (CRE) harbor important pathogens for healthcare-associated infections, including pneumonia,...
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Exercise/Resistance Training and Muscle Stem Cells

Fukada Si, Nakamura A

Skeletal muscle has attracted attention as endocrine organ, because exercise-dependent cytokines called myokines/exerkines are released from skeletal muscle and are involved in systemic functions. While, local mechanical loading to skeletal...
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Study of Conjunctival Microbial Flora in Patients of Intensive Care Unit

Ramani K, Kaliaperumal S, Sarkar S, Sistla S

Purpose: The objective of the study was to evaluate the type of conjunctival microbial flora in intensive care unit patients and their antimicrobial sensitivity pattern. Methods: A total of 272 samples...
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Prevalence of methicillin-resistant Staphylococcus aureus in Iranian children: a systematic review and meta-analysis

Sarrafzadeh F, Sohrevardi SM, Abousaidi H, Mirzaei H

Background: Antibiotic resistance is associated with longer hospitalizations, higher treatment costs, and increased morbidity and mortality rates. Purpose: This study aimed to determine the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in...
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Machine Learning for Antibiotic Resistance Prediction: A Prototype Using Off-the-Shelf Techniques and Entry-Level Data to Guide Empiric Antimicrobial Therapy

Feretzakis G, Sakagianni A, Loupelis E, Kalles D, Skarmoutsou N, Martsoukou M, Christopoulos C, Lada M, Petropoulou S, Velentza A, Michelidou S, Chatzikyriakou R, Dimitrellos E

Objectives: In the era of increasing antimicrobial resistance, the need for early identification and prompt treatment of multi-drug-resistant infections is crucial for achieving favorable outcomes in critically ill patients. As...
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Computed Tomography-Derived Myosteatosis and Metabolic Disorders

Miljkovic I, Vella CA, Allison M

The role of ectopic adipose tissue infiltration into skeletal muscle (i.e., myosteatosis) for metabolic disorders has received considerable and increasing attention in the last 10 years. The purpose of this...
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Ten-Year Prevalence Trends of Phenotypically Identified Community-Associated Methicillin-Resistant Staphylococcus aureus Strains in Clinical Specimens

Yu SH, Lee JH, Kim MC, Choi SH, Chung JW, Lee MK

Background: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains were first detected in hospitals in Korea between the late 2000s and early 2010s. However, there is limited information regarding the prevalence of CA-MRSA...
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Additional Drug Resistance in Patients with Multidrug-resistant Tuberculosis in Korea: a Multicenter Study from 2010 to 2019

Lee T, Lee SJ, Jeon D, Lee HY, Kim HJ, Kang BH, Mok J

Background: Drug-resistance surveillance (DRS) data provide key information for building an effective treatment regimen in patients with multidrug-resistant tuberculosis (MDR-TB). This study was conducted to investigate the patterns and trends of...
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Effects of the Combination of Evogliptin and Leucine on Insulin Resistance and Hepatic Steatosis in High-Fat Diet-Fed Mice

Shin CY, Lee HY, Kim GH, Park SY, Choi WS, Sohn UD

In this study, we aimed to investigate the effects of 8 weeks of treatment with a combination of evogliptin and leucine, a branchedchain amino acid, in mice with high-fat diet...
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