Int J Heart Fail.  2022 Apr;4(2):110-116. 10.36628/ijhf.2022.0005.

Prognostic Value of Short-Term Followup of Multiple Biomarkers After Discharge in Hospitalized Patients With Acute Heart Failure (POSTBIO-HF): Rationale and Study Design

• Cho DH
• Son JW
• Lee CJ
• Choi J
• Kim MN
• Lee JH
• Lee S
• Yang DH
• Cho HJ
• Choi JO
• Kim EJ
• Choi DJ
• Yoo BS

• KMID: 2532552
• DOI: http://doi.org/10.36628/ijhf.2022.0005

Abstract

Several surrogate biomarkers possess prognostic significance for heart failure (HF), and a decline in their respective values may predict clinical improvement. However, data on the prognostic value of these biomarkers during short-term follow-up after discharge in acute decompensated HF are scarce. We aim to evaluate the prognostic value of short-term follow-up of surrogate biomarkers for predicting the prognosis of hospitalized patients with acute decompensated HF. This multi-center, prospective study will enroll consecutive hospitalized patients with acute decompensated HF. All patients will undergo sampling and comparison of biomarkers, including plasma N-terminal pro-brain natriuretic peptide, growth differentiation factor 15, troponin-T, high-sensitivity C-reactive protein, and urinary albumin/creatinine ratio obtained within 1 month and 6 months after discharge from the index admission. The primary endpoint is a composite of cardiovascular mortality or HF hospitalization during 1 year of follow-up. We will investigate the prognostic value of multiple biomarkers for the primary endpoint. This trial will provide robust evidence for novel multibiomarker strategies for acute decompensated HF in real-world settings. Trial Registration: ClinicalTrials.gov Identifier: NCT04437628

Keyword

Biomarkers; Heart failure