Int J Heart Fail.  2022 Apr;4(2):110-116. 10.36628/ijhf.2022.0005.

Prognostic Value of Short-Term Followup of Multiple Biomarkers After Discharge in Hospitalized Patients With Acute Heart Failure (POSTBIO-HF): Rationale and Study Design

Affiliations
  • 1Division of Cardiology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea
  • 2Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
  • 3Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
  • 4Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital, Seoul, Korea
  • 5Division of Cardiology, Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea
  • 6Division of Cardiology, Department of Internal Medicine, Dongtan Hospital, Hallym University, Hwaseong, Korea
  • 7Division of Cardiology, Department of Internal Medicine, Kyungpook National University Hospital, Taegu, Korea
  • 8Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
  • 9Division of Cardiology, Department of Internal Medicine, Sungkyunkwan University College of Medicine, Seoul, Korea
  • 10Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea
  • 11Division of Cardiology, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea

Abstract

Several surrogate biomarkers possess prognostic significance for heart failure (HF), and a decline in their respective values may predict clinical improvement. However, data on the prognostic value of these biomarkers during short-term follow-up after discharge in acute decompensated HF are scarce. We aim to evaluate the prognostic value of short-term follow-up of surrogate biomarkers for predicting the prognosis of hospitalized patients with acute decompensated HF. This multi-center, prospective study will enroll consecutive hospitalized patients with acute decompensated HF. All patients will undergo sampling and comparison of biomarkers, including plasma N-terminal pro-brain natriuretic peptide, growth differentiation factor 15, troponin-T, high-sensitivity C-reactive protein, and urinary albumin/creatinine ratio obtained within 1 month and 6 months after discharge from the index admission. The primary endpoint is a composite of cardiovascular mortality or HF hospitalization during 1 year of follow-up. We will investigate the prognostic value of multiple biomarkers for the primary endpoint. This trial will provide robust evidence for novel multibiomarker strategies for acute decompensated HF in real-world settings. Trial Registration: ClinicalTrials.gov Identifier: NCT04437628

Keyword

Biomarkers; Heart failure
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