Chonnam Med J.  2020 Jan;56(1):1-5. 10.4068/cmj.2020.56.1.1.

Scavenger Receptor Class A to E Involved in Various Cancers

• Ryu S
• Howland A
• Song B
• Youn C
• Song PI

• KMID: 2468139
• DOI: http://doi.org/10.4068/cmj.2020.56.1.1

Abstract

Scavenger receptors typically bind to multiple ligands on a cell surface, including endogenous and modified host-derived molecules and microbial pathogens. They promote the elimination of degraded or harmful substances such as non-self or altered-self targets through endocytosis, phagocytosis, and adhesion. Currently, scavenger receptors are subdivided into eight classes based on several variations in their sequences due to alternative splicing. Since recent studies indicate targeting scavenger receptors has been involved in cancer prognosis and carcinogenesis, we will focus on the current knowledge about the emerging role of scavenger receptor classes A to E in cancer progression.

Keyword

Scavenger Receptor; Scavenger Receptor Class A; Macrophages; Lectin-Like Oxidized LDL Receptor 1

MeSH Terms

Alternative Splicing
Carcinogenesis
Endocytosis
Ligands
Macrophages
Phagocytosis
Prognosis
Receptors, Scavenger*
Ligands
Receptors, Scavenger

Figure

• 

  FIG. 1 Scavenger receptors class A, B, D, and E.

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