Chonnam Med J.  2020 Jan;56(1):1-5. 10.4068/cmj.2020.56.1.1.

Scavenger Receptor Class A to E Involved in Various Cancers

Affiliations
  • 1Boston University School of Medicine, Boston, MA, USA.
  • 2University of Colorado Denver School of Medicine, Aurora, CO, USA.
  • 3University of Denver, Denver, CO, USA.
  • 4Department of Biomedical Science, Research Center for Proteinaceous Materials, Chosun University School of Medicine, Gwangju, Korea.
  • 5InClinica, Wayne, PA, USA. peterisong.academia@gmail.com

Abstract

Scavenger receptors typically bind to multiple ligands on a cell surface, including endogenous and modified host-derived molecules and microbial pathogens. They promote the elimination of degraded or harmful substances such as non-self or altered-self targets through endocytosis, phagocytosis, and adhesion. Currently, scavenger receptors are subdivided into eight classes based on several variations in their sequences due to alternative splicing. Since recent studies indicate targeting scavenger receptors has been involved in cancer prognosis and carcinogenesis, we will focus on the current knowledge about the emerging role of scavenger receptor classes A to E in cancer progression.

Keyword

Scavenger Receptor; Scavenger Receptor Class A; Macrophages; Lectin-Like Oxidized LDL Receptor 1

MeSH Terms

Alternative Splicing
Carcinogenesis
Endocytosis
Ligands
Macrophages
Phagocytosis
Prognosis
Receptors, Scavenger*
Ligands
Receptors, Scavenger

Figure

  • FIG. 1 Scavenger receptors class A, B, D, and E.


Reference

1. Matsumoto A, Naito M, Itakura H, Ikemoto S, Asaoka H, Hayakawa I, et al. Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions. Proc Natl Acad Sci U S A. 1990; 87:9133–9137.
Article
2. Ben J, Jin G, Zhang Y, Ma B, Bai H, Chen J, et al. Class A scavenger receptor deficiency exacerbates lung tumorigenesis by cultivating a procarcinogenic microenvironment in humans and mice. Am J Respir Crit Care Med. 2012; 186:763–772.
Article
3. Caruso C, Balistreri CR, Candore G, Carruba G, Colonna-Romano G, Di Bona D, et al. Polymorphisms of pro-inflammatory genes and prostate cancer risk: a pharmacogenomic approach. Cancer Immunol Immunother. 2009; 58:1919–1933.
Article
4. Krieger M, Abrams JM, Lux A, Steller H. Molecular flypaper, atherosclerosis, and host defense: structure and function of the macrophage scavenger receptor. Cold Spring Harb Symp Quant Biol. 1992; 57:605–609.
Article
5. Krieger M, Acton S, Ashkenas J, Pearson A, Penman M, Resnick D. Molecular flypaper, host defense, and atherosclerosis. Structure, binding properties, and functions of macrophage scavenger receptors. J Biol Chem. 1993; 268:4569–4572.
Article
6. Krieger M, Herz J. Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu Rev Biochem. 1994; 63:601–637.
Article
7. Kodama T, Freeman M, Rohrer L, Zabrecky J, Matsudaira P, Krieger M. Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Nature. 1990; 343:531–535.
Article
8. Krieger M. Molecular flypaper and atherosclerosis: structure of the macrophage scavenger receptor. Trends Biochem Sci. 1992; 17:141–146.
Article
9. Yu X, Guo C, Fisher PB, Subjeck JR, Wang XY. Scavenger receptors: emerging roles in cancer biology and immunology. Adv Cancer Res. 2015; 128:309–364.
10. Facciponte JG, MacDonald IJ, Wang XY, Kim H, Manjili MH, Subjeck JR. Heat shock proteins and scavenger receptors: role in adaptive immune responses. Immunol Invest. 2005; 34:325–342.
Article
11. Murshid A, Gong J, Stevenson MA, Calderwood SK. Heat shock proteins and cancer vaccines: developments in the past decade and chaperoning in the decade to come. Expert Rev Vaccines. 2011; 10:1553–1568.
Article
12. Zhu H, Fang X, Zhang D, Wu W, Shao M, Wang L, et al. Membrane-bound heat shock proteins facilitate the uptake of dying cells and cross-presentation of cellular antigen. Apoptosis. 2016; 21:96–109.
Article
13. Yu G, Tseng GC, Yu YP, Gavel T, Nelson J, Wells A, et al. CSR1 suppresses tumor growth and metastasis of prostate cancer. Am J Pathol. 2006; 168:597–607.
Article
14. Luo HR, Liu Y, Wan XD, Li JL, Wu M, Zhang QM, et al. Sumoylation negatively regulates CSR1-dependent prostate cancer cell death. Cell Physiol Biochem. 2018; 46:1861–1867.
Article
15. Bock AJ, Nymoen DA, Brenne K, Kærn J, Davidson B. SCARA3 mRNA is overexpressed in ovarian carcinoma compared with breast carcinoma effusions. Hum Pathol. 2012; 43:669–674.
Article
16. Armengol C, Bartolí R, Sanjurjo L, Serra I, Amézaga N, Sala M, et al. Role of scavenger receptors in the pathophysiology of chronic liver diseases. Crit Rev Immunol. 2013; 33:57–96.
Article
17. Liu H, Hu J, Pan H, Luo D, Huang M, Xu W. CSN5 promotes hepatocellular carcinoma progression by SCARA5 inhibition through suppressing β-catenin ubiquitination. Dig Dis Sci. 2018; 63:155–165.
Article
18. You K, Su F, Liu L, Lv X, Zhang J, Zhang Y, et al. SCARA5 plays a critical role in the progression and metastasis of breast cancer by inactivating the ERK1/2, STAT3, and AKT signaling pathways. Mol Cell Biochem. 2017; 435:47–58.
Article
19. Nakagawa-Toyama Y, Hirano K, Tsujii K, Nishida M, Miyagawa J, Sakai N, et al. Human scavenger receptor class B type I is expressed with cell-specific fashion in both initial and terminal site of reverse cholesterol transport. Atherosclerosis. 2005; 183:75–83.
Article
20. Yang X, Sethi A, Yanek LR, Knapper C, Nordestgaard BG, Tybjærg-Hansen A, et al. SCARB1 gene variants are associated with the phenotype of combined high high-density lipoprotein cholesterol and high lipoprotein (a). Circ Cardiovasc Genet. 2016; 9:408–418.
Article
21. Cedó L, Reddy ST, Mato E, Blanco-Vaca F, Escolà-Gil JC. HDL and LDL: potential new players in breast cancer development. J Clin Med. 2019; 8:E853.
Article
22. Wang HH, Garruti G, Liu M, Portincasa P, Wang DQ. Cholesterol and lipoprotein metabolism and atherosclerosis: recent advances in reverse cholesterol transport. Ann Hepatol. 2017; 16 Suppl 1:S27–S42.
Article
23. Graf GA, Roswell KL, Smart EJ. 17beta-Estradiol promotes the up-regulation of SR-BII in HepG2 cells and in rat livers. J Lipid Res. 2001; 42:1444–1449.
Article
24. Gillard BK, Bassett GR, Gotto AM Jr, Rosales C, Pownall HJ. Scavenger receptor B1 (SR-B1) profoundly excludes high density lipoprotein (HDL) apolipoprotein AII as it nibbles HDL-cholesteryl ester. J Biol Chem. 2017; 292:8864–8873.
Article
25. Shen WJ, Asthana S, Kraemer FB, Azhar S. Scavenger receptor B type 1: expression, molecular regulation, and cholesterol transport function. J Lipid Res. 2018; 59:1114–1131.
Article
26. Shen WJ, Azhar S, Kraemer FB. SR-B1: a unique multifunctional receptor for cholesterol influx and efflux. Annu Rev Physiol. 2018; 80:95–116.
Article
27. Wang J, Li Y. CD36 tango in cancer: signaling pathways and functions. Theranostics. 2019; 9:4893–4908.
Article
28. Hale JS, Li M, Sinyuk M, Jahnen-Dechent W, Lathia JD, Silverstein RL. Context dependent role of the CD36--thrombospondin--histidine-rich glycoprotein axis in tumor angiogenesis and growth. PLoS One. 2012; 7:e40033.
29. Woo MS, Yang J, Beltran C, Cho S. Cell surface CD36 protein in monocyte/macrophage contributes to phagocytosis during the resolution phase of ischemic stroke in mice. J Biol Chem. 2016; 291:23654–23661.
Article
30. Oury C. CD36: linking lipids to the NLRP3 inflammasome, atherogenesis and atherothrombosis. Cell Mol Immunol. 2014; 11:8–10.
Article
31. Lawler PR, Lawler J. Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2. Cold Spring Harb Perspect Med. 2012; 2:a006627.
Article
32. Simantov R, Febbraio M, Silverstein RL. The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein. Matrix Biol. 2005; 24:27–34.
Article
33. Uray IP, Liang Y, Hyder SM. Estradiol down-regulates CD36 expression in human breast cancer cells. Cancer Lett. 2004; 207:101–107.
Article
34. DeFilippis RA, Chang H, Dumont N, Rabban JT, Chen YY, Fontenay GV, et al. CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues. Cancer Discov. 2012; 2:826–839.
Article
35. Song L, Lee C, Schindler C. Deletion of the murine scavenger receptor CD68. J Lipid Res. 2011; 52:1542–1550.
Article
36. Jiang Z, Shih DM, Xia YR, Lusis AJ, de Beer FC, de Villiers WJ, et al. Structure, organization, and chromosomal mapping of the gene encoding macrosialin, a macrophage-restricted protein. Genomics. 1998; 50:199–205.
Article
37. Yang L, Yang L, Dong C, Li L. The class D scavenger receptor CD68 contributes to mouse chronic liver injury. Immunol Res. 2018; 66:414–424.
Article
38. Ni YH, Ding L, Huang XF, Dong YC, Hu QG, Hou YY. Microlocalization of CD68+ tumor-associated macrophages in tumor stroma correlated with poor clinical outcomes in oral squamous cell carcinoma patients. Tumour Biol. 2015; 36:5291–5298.
Article
39. Jézéquel P, Campion L, Spyratos F, Loussouarn D, Campone M, Guérin-Charbonnel C, et al. Validation of tumor-associated macrophage ferritin light chain as a prognostic biomarker in nodenegative breast cancer tumors: a multicentric 2004 national PHRC study. Int J Cancer. 2012; 131:426–437.
Article
40. Ni C, Yang L, Xu Q, Yuan H, Wang W, Xia W, et al. CD68- and CD163-positive tumor infiltrating macrophages in non-metastatic breast cancer: a retrospective study and meta-analysis. J Cancer. 2019; 10:4463–4472.
Article
41. Meng Y, Beckett MA, Liang H, Mauceri HJ, van Rooijen N, Cohen KS, et al. Blockade of tumor necrosis factor alpha signaling in tumor-associated macrophages as a radiosensitizing strategy. Cancer Res. 2010; 70:1534–1543.
Article
42. Balzan S, Lubrano V. LOX-1 receptor: a potential link in atherosclerosis and cancer. Life Sci. 2018; 198:79–86.
Article
43. Joo H, Li D, Dullaers M, Kim TW, Duluc D, Upchurch K, et al. C-type lectin-like receptor LOX-1 promotes dendritic cell-mediated class-switched B cell responses. Immunity. 2014; 41:592–604.
Article
44. Hirsch HA, Iliopoulos D, Joshi A, Zhang Y, Jaeger SA, Bulyk M, et al. A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell. 2010; 17:348–361.
Article
45. Khaidakov M, Mitra S, Kang BY, Wang X, Kadlubar S, Novelli G, et al. Oxidized LDL receptor 1 (OLR1) as a possible link between obesity, dyslipidemia and cancer. PLoS One. 2011; 6:e20277.
Article
46. Kumari S, Achazi K, Dey P, Haag R, Dernedde J. Design and synthesis of PEG-Oligoglycerol sulfates as multivalent inhibitors for the scavenger receptor LOX-1. Biomacromolecules. 2019; 20:1157–1166.
Article
47. Jeannin P, Bottazzi B, Sironi M, Doni A, Rusnati M, Presta M, et al. Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors. Immunity. 2005; 22:551–560.
Article
48. Oh S, Joo H. LOX-1 boosts immunity. Oncotarget. 2015; 6:21763–21764.
Article
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