Psychiatry Investig.  2019 Dec;16(12):948-953. 10.30773/pi.2019.0110.

Biomarkers in Drug Free Subjects with Depression : Correlation with Tryptophan

• Samad N
• Yasmin F
• Manzoor N

• KMID: 2467300
• DOI: http://doi.org/10.30773/pi.2019.0110

Abstract

OBJECTIVE
Depression is a prevalent condition that is costly to individuals and society. In view of a role of tryptophan (TRP), selenium (Se), vitamin D (Vit D), magnesium (Mg) and serotonin in depression, the present study concerns to evaluate the circulating levels of TRP, Se, Vit D, Mg and serotonin in depression as well as the correlation between TRP and other serum analytes is also established.
METHODS
Healthy (n=48) and depressed (n=48) subjects were recruited and their blood samples were obtained after an overnight fast of 12 h, serum was stored for the determination of levels of TRP, Se, Vit D, Mg, and serotonin.
RESULTS
show that levels of TRP, Se, Vit D, Mg, and serotonin were decreased in the depressed patient when compared to normal subjects. There is a direct correlation between TRP and Vit D, and TRP and Se while the inverse correlation between TRP and Mg, and TRP and serotonin in depressed subjects. The association among TRP and other biomarkers is non-significant.
CONCLUSION
In conclusion, depression is associated with deficiency of TRP, Se, Vit D, Mg, and serotonin displays the characteristics of biomarkers. The correlation between TRP and other biomarkers/trace elements is also important in depression.

Keyword

Depression; Tryptophan; Selenium; Vitamin D; Serotonin; Magnesium; Trace elements; Biomarkers

MeSH Terms

Biomarkers*
Depression*
Humans
Magnesium
Selenium
Serotonin
Trace Elements
Tryptophan*
Vitamin D
Biomarkers
Magnesium
Selenium
Serotonin
Trace Elements
Tryptophan
Vitamin D