J Menopausal Med.  2019 Dec;25(3):142-148. 10.6118/jmm.19010.

The Importance of Education regarding the Effects of Anticancer Treatment on Fertility and Ovarian Function in the Female Patients with Breast Cancer

• Shin S
• Kim J
• Kim D
• Kim H
• Lee S
• Kim SH
• Chae HD
• Kang BM
• Kim MK
• Chae EY
• Kim JE
• Chung IY
• Kim HJ

• KMID: 2466829
• DOI: http://doi.org/10.6118/jmm.19010

Abstract

OBJECTIVES
Female breast cancer patients generally have limited knowledge regarding issues related to preservation of ovarian function and fertility. The present study aimed to explore the change in the understanding of these issues when female breast cancer patients are educated and counseled about ovarian function and fertility after anticancer treatment.
METHODS
One hundred nine young female breast cancer patients completed a questionnaire, which revealed their thoughts and opinions before and after receiving the education about ovarian function and fertility. Their responses were analyzed to determine the impact of the education on their perception and understanding of the aforementioned issues.
RESULTS
The objective survey had four main themes: planning and desire for children, degree of baseline understanding of the effects of anticancer therapy on fertility and ovarian function, resultant change in cognition after education about cancer treatment and its relationship with fertility, and need for education regarding the types of therapies received and their effects on subsequent ovarian function and fertility before treatment.
CONCLUSIONS
The preservation of ovarian function and fertility is an important factor that must be included in the discussion prior to initiation of anticancer therapy. Although the study results do not have high educational effectiveness or a high satisfaction with education, there is a need for information and education regarding the impact of anticancer treatment on preservation of ovarian function and fertility.

Keyword

Breast cancer; Education; Preservation of fertility and ovarian function

MeSH Terms

Breast Neoplasms*
Breast*
Child
Cognition
Education*
Female*
Fertility*
Humans

Reference

1. National Cancer Information Center. Incidence by cancer type. Il-san: National Cancer Information Center;cited 2016 Dec 27. Available from: https://www.cancer.go.kr/lay1/S1T639C641/contents.do.

2. National Cancer Information Center. 5-year relative cancer survival rate. Il-san: National Cancer Information Center;cited 2016 Dec 27. Available from: https://www.cancer.go.kr/lay1/S1T648C650/contents.do.

3. Merlo DF, Ceppi M, Filiberti R, Bocchini V, Znaor A, Gamulin M, et al. Breast cancer incidence trends in European women aged 20-39 years at diagnosis. Breast Cancer Res Treat. 2012; 134:363–370.

4. Anders CK, Johnson R, Litton J, Phillips M, Bleyer A. Breast cancer before age 40 years. Semin Oncol. 2009; 36:237–249.

5. Azim HA Jr, Partridge AH. Biology of breast cancer in young women. Breast Cancer Res. 2014; 16:427.

6. Lee SJ, Schover LR, Partridge AH, Patrizio P, Wallace WH, Hagerty K, et al. American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. J Clin Oncol. 2006; 24:2917–2931.

7. Hulvat MC, Jeruss JS. Maintaining fertility in young women with breast cancer. Curr Treat Options Oncol. 2009; 10:308–317.

8. Loren AW, Mangu PB, Beck LN, Brennan L, Magdalinski AJ, Partridge AH, et al. Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol. 2013; 31:2500–2510.

9. Dizon DS, Suzin D, McIlvenna S. Sexual health as a survivorship issue for female cancer survivors. Oncologist. 2014; 19:202–210.

10. King L, Quinn GP, Vadaparampil ST, Gwede CK, Miree CA, Wilson C, et al. Oncology nurses' perceptions of barriers to discussion of fertility preservation with patients with cancer. Clin J Oncol Nurs. 2008; 12:467–476.

11. Quinn GP, Vadaparampil ST, King L, Miree CA, Wilson C, Raj O, et al. Impact of physicians' personal discomfort and patient prognosis on discussion of fertility preservation with young cancer patients. Patient Educ Couns. 2009; 77:338–343.

12. Ellis SJ, Wakefield CE, McLoone JK, Robertson EG, Cohn RJ. Fertility concerns among child and adolescent cancer survivors and their parents: a qualitative analysis. J Psychosoc Oncol. 2016; 34:347–362.

13. Zebrack BJ, Casillas J, Nohr L, Adams H, Zeltzer LK. Fertility issues for young adult survivors of childhood cancer. Psychooncology. 2004; 13:689–699.

14. Tschudin S, Bitzer J. Psychological aspects of fertility preservation in men and women affected by cancer and other life-threatening diseases. Hum Reprod Update. 2009; 15:587–597.

15. Balthazar U, Fritz MA, Mersereau JE. Fertility preservation: a pilot study to assess previsit patient knowledge quantitatively. Fertil Steril. 2011; 95:1913–1916.

16. Schover LR. Patient attitudes toward fertility preservation. Pediatr Blood Cancer. 2009; 53:281–284.

17. Partridge AH, Gelber S, Peppercorn J, Sampson E, Knudsen K, Laufer M, et al. Web-based survey of fertility issues in young women with breast cancer. J Clin Oncol. 2004; 22:4174–4183.

18. Wallace WH, Smith AG, Kelsey TW, Edgar AE, Anderson RA. Fertility preservation for girls and young women with cancer: population-based validation of criteria for ovarian tissue cryopreservation. Lancet Oncol. 2014; 15:1129–1136.

19. Kim J, Deal AM, Balthazar U, Kondapalli LA, Gracia C, Mersereau JE. Fertility preservation consultation for women with cancer: are we helping patients make high-quality decisions? Reprod Biomed Online. 2013; 27:96–103.