J Vet Sci.  2019 Sep;20(5):e40. 10.4142/jvs.2019.20.e40.

Pharmacokinetics/Pharmacodynamics models of veterinary antimicrobial agents

• Luo W
• Chen D
• Wu M
• Li Z
• Tao Y
• Liu Q
• Pan Y
• Qu W
• Yuan Z
• Xie S

• KMID: 2464090
• DOI: http://doi.org/10.4142/jvs.2019.20.e40

Abstract

Misuse and abuse of veterinary antimicrobial agents have led to an alarming increase in bacterial resistance, clinical treatment failure, and drug residues. To address these problems, consistent and appropriate dosage regimens for veterinary antimicrobial agents are needed. Pharmacokinetics/Pharmacodynamics (PK/PD) models have been widely used to establish rational dosage regimens for veterinary antimicrobial agents that can achieve effective prevention and treatment of bacterial diseases and avoid the development of bacterial resistance. This review introduces building methods for PK/PD models and describes current PK/PD research progress toward rational dosage regimens for veterinary antimicrobial agents. Finally, the challenges and prospects of PK/PD models in the design of dosage regimens for veterinary antimicrobial agents are reviewed. This review will help to increase awareness of PK/PD modeling among veterinarians and hopefully promote its development and future use.

Keyword

PK/PD models; dosage regimens; drug residues; bacterial infections; antimicrobial agents

MeSH Terms

Anti-Infective Agents*
Bacterial Infections
Drug Residues
Humans
Treatment Failure
Veterinarians
Anti-Infective Agents