Osteoporos Sarcopenia.  2019 Sep;5(3):75-81. 10.1016/j.afos.2019.09.001.

A comparison of 6 osteoporosis risk assessment tools among postmenopausal women in Kuala Lumpur, Malaysia

Affiliations
  • 1Division of Pharmacy Practice and Policy, School of Pharmacy, University of Nottingham, University Park, Nottingham, UK. lishean.toh@nottingham.ac.uk
  • 2Department of Primary Care Medicine, University of Malaya Primary Care Research Group (UMPCRG), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  • 3School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Selangor, Malaysia.
  • 4School of Medicine, University of Nottingham, University Park, Nottingham, UK.
  • 5Division of Pharmacy, School of Medicine, Faculty of Health, University of Tasmania, Tasmania, Australia.
  • 6School of Pharmacy, Faculty of Science and Engineering, University of Nottingham, Selangor, Malaysia.
  • 7Department of Radiology, University of Foggia, Foggia, Italy.

Abstract


OBJECTIVES
To compare and assess the performance of 6 osteoporosis risk assessment tools for screening osteoporosis in Malaysian postmenopausal women.
METHODS
Six osteoporosis risk assessments tools (the Simple Calculated Osteoporosis Risk Estimation [SCORE], the Osteoporosis Risk Assessment Instrument, the Age Bulk One or Never Estrogen, the body weight, the Malaysian Osteoporosis Screening Tool, and the Osteoporosis Self-Assessment Tool for Asians) were used to screen postmenopausal women who had not been previously diagnosed with osteoporosis/osteopenia. These women also underwent a dual-energy X-ray absorptiometry (DXA) scan to confirm the absence or presence of osteoporosis.
RESULTS
A total of 164/224 participants were recruited (response rate, 73.2%), of which only 150/164 (91.5%) completed their DXA scan. Sixteen participants (10.7%) were found to have osteoporosis, whilst 65/150 (43.3%) were found to have osteopenia. Using precision-recall curves, the recall of the tools ranged from 0.50 to 1.00, whilst precision ranged from 0.04 to 0.14. The area under the curve (AUC) ranged from 0.027 to 0.161. The SCORE had the best balance between recall (1.00), precision (0.04-0.12), and AUC (0.072-0.161).
CONCLUSIONS
We found that the SCORE had the best balance between recall, precision, and AUC among the 6 screening tools that were compared among Malaysian postmenopausal women.

Keyword

Osteoporosis; Screening; Osteoporosis self-assessment tool for asians; Risk assessment; Performance comparison

MeSH Terms

Absorptiometry, Photon
Area Under Curve
Body Weight
Bone Diseases, Metabolic
Estrogens
Female
Humans
Malaysia*
Mass Screening
Osteoporosis*
Risk Assessment*
Self-Assessment
Estrogens
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