Psychiatry Investig.
2018 Jan;15(1):84-89. 10.4306/pi.2018.15.1.84.
Haplotype Association of the MAP2K5 Gene with Antipsychotics-Induced Symptoms of Restless Legs Syndrome among Patients with Schizophrenia
- Affiliations
-
- 1Department of Psychiatry, Gil Medical Center, Gachon University School of Medicine, Incheon, Republic of Korea.
- 2Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
- 3Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea.
- 4Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea. leehjeong@korea.ac.kr
- KMID: 2456127
- DOI: http://doi.org/10.4306/pi.2018.15.1.84
Abstract
OBJECTIVE
Restless legs syndrome (RLS) is considered a genetic disease and, following a genome-wide association study conducted in 2007, the mitogen-activated protein kinase 5 (MAP2K5) gene has been regarded as the promising candidate gene for RLS. The present study investigated whether polymorphisms of MAP2K5 are associated with antipsychotics-induced RLS in schizophrenia.
METHODS
We assessed antipsychotics-induced RLS symptoms in 190 Korean schizophrenic patients using the diagnostic criteria of the International Restless Legs Syndrome Study Group. Five single-nucleotide polymorphisms (SNPs) of MAP2K5 were genotyped. We investigated genetic and haplotypic associations of these five SNPs with the risk of antipsychotics-induced RLS symptoms.
RESULTS
We divided the 190 subjects into 2 groups: 1) those with RLS symptoms (n=96) and 2) those without RLS symptoms (n=94). There were no significant intergroup differences in the distributions of the genotypes and alleles of the rs1026732, rs11635424, rs12593813, rs4489954, and rs3784709 SNPs. However, the haplotype analysis showed that the G-G-G-G-T (rs1026732-rs11635424-rs12593813-rs4489954-rs3784709) haplotype was associated with RLS symptoms (permutation p=0.033).
CONCLUSION
These data suggest that a haplotype of MAP2K5 polymorphisms confers increased susceptibility to antipsychotics-induced RLS symptoms in schizophrenic patients.
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