Intest Res.  2019 Jul;17(3):427-433. 10.5217/ir.2018.00152.

Evaluation of symptoms and symptom combinations in histamine intolerance

Affiliations
  • 1Practice for General Internal Medicine, Bruck, Austria. w.schnedl@dr-schnedl.at
  • 2Institute of Pathophysiology, Otto Loewi Research Centre, Medical University of Graz, Graz, Austria.
  • 3Institute of Laboratory Medicine, General Hospital Steyr, Steyr, Austria.
  • 4Das Kinderwunsch Institut Schenk GmbH, Dobl, Austria.
  • 5Clinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Graz, Austria.

Abstract

BACKGROUND/AIMS
Food intolerance/malabsorption, particularly histamine intolerance (HIT), may cause nonspecific functional gastrointestinal and extraintestinal symptoms. We evaluated gastrointestinal and extraintestinal symptoms in patients with HIT.
METHODS
In an analysis of outpatients' charts we identified 133 patients, who presented with recurring nonspecific functional gastrointestinal, extraintestinal symptoms, and a diamine oxidase value <10 U/mL, indicative of HIT. A standardized anonymous questionnaire with symptoms of HIT based on known symptoms and the 4 histamine receptors including gastrointestinal, cardiovascular, respiratory and skin complaints was developed, and sent by mail to the patients.
RESULTS
In the 62 patients that completed the questionnaire, bloating was the most common and most serious symptom. Other commonly reported gastrointestinal symptoms were postprandial fullness, diarrhea, abdominal pain, and constipation. The presence of 2 from a list of 24 symptoms resulted in 276 various symptom combinations. From calculated 2.024 possible combinations of 3 symptoms the patients with HIT presented 1.975 combinations.
CONCLUSIONS
The knowledge of this wide variability of symptoms and complex symptom combinations in patients with HIT may help to clinically recognize and diagnose HIT.

Keyword

Diamine oxidase; Histamine; Irritable bowel syndrome; Gluten; Gastrointestinal diseases

MeSH Terms

Abdominal Pain
Amine Oxidase (Copper-Containing)
Anonyms and Pseudonyms
Constipation
Diarrhea
Gastrointestinal Diseases
Glutens
Histamine*
Humans
Irritable Bowel Syndrome
Postal Service
Receptors, Histamine
Skin
Amine Oxidase (Copper-Containing)
Glutens
Histamine
Receptors, Histamine
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