Ann Pediatr Endocrinol Metab.  2019 Jun;24(2):104-107. 10.6065/apem.2019.24.2.104.

Serum osteocalcin levels in overweight children

• Oh SB
• Lee WY
• Nam HK
• Rhie YJ
• Lee KH

• KMID: 2452086
• DOI: http://doi.org/10.6065/apem.2019.24.2.104

Abstract

PURPOSE
Bone plays a role in glucose metabolism through the release of uncarboxylated osteocalcin into the systemic circulation. The identified novel roles for osteocalcin include increasing insulin secretion and sensitivity, energy expenditure, reduction of fat mass, and mitochondrial proliferation and functional enhancement. This study aimed to determine serum osteocalcin levels in overweight children and to investigate the relationships of osteocalcin with glucose metabolism and insulin sensitivity.
METHODS
After overnight fasting, serum osteocalcin levels were measured in overweight (n=50) children between 6.0 and 12.9 years of age and nonoverweight controls (n=60). Height, weight, fasting serum glucose, insulin, alkaline phosphatase, total cholesterol, and 25 hydroxy vitamin D₃ (25(OH)VitD₃) were also measured in all subjects.
RESULTS
There were significant differences in serum osteocalcin levels between the overweight and control groups (64.00±20.44 vs. 89.56±28.63, P<0.001). Serum osteocalcin levels were inversely correlated with body mass index (BMI) (r=-0.283, P=0.003), weight standard deviation score (SDS) (r=-0.222, P=0.020), BMI SDS (r=-0.297, P=0.002), insulin (r=-0.313, P=0.001), and homeostasis model assessment of insulin resistance (HOMA-IR) index (r=-0.268, P=0.005). In the subsequent multiple regression analyses, BMI, HOMA-IR, and age were determined to be independent predicting factors for serum osteocalcin.
CONCLUSIONS
Our findings showed associations of serum osteocalcin with glucose metabolism and insulin sensitivity in overweight children, but we could not establish a causal relationship.

Keyword

Overweight; Glucose; Metabolism; Osteocalcin

MeSH Terms

Alkaline Phosphatase
Blood Glucose
Body Mass Index
Child*
Cholesterol
Energy Metabolism
Fasting
Glucose
Homeostasis
Humans
Insulin
Insulin Resistance
Metabolism
Osteocalcin*
Overweight*
Vitamins
Alkaline Phosphatase
Cholesterol
Glucose
Insulin
Osteocalcin
Vitamins

Reference

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