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Sweroside plays a role in mitigating high glucose-induced damage in human renal tubular epithelial HK-2 cells by regulating the SIRT1/NF-κB signaling pathway

Ma X, Guo Z, Zhao W, Chen L

Sweroside is a natural monoterpene derived from Swertia pseudochinensis Hara. Recently, studies have shown that sweroside exhibits a variety of biological activities, such as anti-inflammatory, antioxidant, and hypoglycemic effects. However, its...
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Cornuside inhibits glucose-induced proliferation and inflammatory response of mesangial cells

Li X, Guo L, Huang F, Xu W, Peng G

Cornuside is a secoiridoid glucoside compound extracted from the fruits of Cornus officinalis. Cornuside has immunomodulatory and anti-inflammatory properties; however, its potential therapeutic effects on diabetic nephropathy (DN) have not...
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Significance of Triglyceride-to-HighDensity Lipoprotein Cholesterol Ratio in Children with Non-Alcoholic Fatty Liver Disease

Kim HJ

Purpose: Nonalcoholic fatty liver disease (NAFLD) is associated with obesity and metabolic syndrome. This study evaluated the significance of markers such as the triglyceride-to-highdensity lipoprotein cholesterol (TG/HDL-C) ratio and TG-glucose...
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Clinical and Lifestyle Determinants of Continuous Glucose Monitoring Metrics in Insulin-Treated Patients with Type 2 Diabetes Mellitus

Lee DY, Kim N, Jung I, Park SY, Yu JH, Seo JA, Kim J, Kim KJ, Kim NH, Yoo HJ, Kim SG, Choi KM, Baik SH, Park SM, Kim NH

Background: There was limited evidence to evaluate the association between lifestyle habits and continuous glucose monitoring (CGM) metrics. Thus, we aimed to depict the behavioral and metabolic determinants of CGM...
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Efficacy and Safety of Enavogliflozin versus Dapagliflozin as Add-on to Metformin in Patients with Type 2 Diabetes Mellitus: A 24-Week, Double-Blind, Randomized Trial

Han KA, Kim YH, Kim DM, Lee BW, Chon S, Sohn TS, Jeong IK, Hong EG, Son JW, Nah JJ, Song HR, Cho SI, Cho SA, Yoon KH

Background: Enavogliflozin is a novel sodium-glucose cotransporter-2 inhibitor currently under clinical development. This study evaluated the efficacy and safety of enavogliflozin as an add-on to metformin in Korean patients with...
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The Benefits Of Continuous Glucose Monitoring In Pregnancy

Yoo JH, Kim JH

Previous studies have consistently demonstrated the positive effects of continuous glucose monitoring (CGM) on glycemic outcomes and complications of diabetes in people with type 1 diabetes. Guidelines now consider CGM...
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Risk of Cause-Specific Mortality across Glucose Spectrum in Elderly People: A Nationwide Population-Based Cohort Study

Lee J, Kim HS, Song KH, Yoo SJ, Han K, Lee SH, Committee of Big Data, Korean Endocrine Society

Background: This study investigated the risk of cause-specific mortality according to glucose tolerance status in elderly South Koreans. Methods: A total of 1,292,264 individuals aged ≥65 years who received health examinations...
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Characteristics of the Latest Therapeutic Agent for Diabetes

Yun N

The latest therapeutic agent for diabetes is characterized by a longer lasting blood glucose control effect than existing treatments and stable blood glucose control. In addition, it has the advantage...
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2023 Clinical Practice Guidelines for Diabetes: Continuous Glucose Monitoring and Insulin Pumps

Jin SM

With the expanding use of continuous glucose monitoring (CGM) and insulin pumps worldwide, several international guidelines dedicated to diabetes technology have been developed. Recently, the Korean Diabetes Association released a...
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Development of a Systematic Quality Control Program for Point-of-Care Glucose Testing

Jo YH, Choi S, Lee JJ, Kim JG, Lee YW

Background: While glucose point-of-care testing (POCT) is widely utilized, it is often carried out by clinical staff who may lack specific test-related training, potentially leading to inadequate quality control (QC)...
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Report of the Korean Association of External Quality Assessment Service on Accuracy-Based Glucose Testing (2022)

Lee JH, Jun SH, Lee K, Song J

As part of the clinical chemistry program of the Korean Association of External Quality Assessment Service, we organized trials to conduct external quality assessment of serum glucose in 2022. We...
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Anticancer effect of metformin alone and in combination with 2-deoxy-D-glucose on mouse T cell lymphoma EL4 cells

Kim SY, Joo HG

Metformin is a treatment used widely for non-insulin-dependent diabetes mellitus with few side effects and acts by inhibiting hepatic gluconeogenesis and glucose absorption from the gastrointestinal tract. Lymphoma is one...
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Association between Prediabetes and Meal Patterns Related to Meal Sharing among Korean Young Adults: Eighth Korean National Health and Nutrition Examination Survey, 2019–2020

Kim S, Kim S, Kim Y, Seo S, Chung YJ, Kim SC

Background: The prevalence of diabetes among young adults is on the rise, and lifestyle modifications during the pre-diabetic stage have proven highly effective in preventing the progression of diabetes. Given...
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Prepregnancy Glucose Levels Within Normal Range and Its Impact on Obstetric Complications in Subsequent Pregnancy: A Population Cohort Study

Kim HY, Ahn KH, Cho GJ, Hong SC, Oh MJ, Kim HJ

Background We sought to identify the influence of prepregnancy glucose levels on obstetric complications in subsequent pregnancy. Methods Women in Republic of Korea who had given birth between January 1st, 2007 and December...
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The Cardiovascular Effect of Tirzepatide: A Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Polypeptide Dual Agonist

Cho YK, Lee YL, Jung CH

Glucagon-like peptide-1 (GLP-1) receptor agonists have been used extensively in the clinic and have an established safety profile in cardiovascular disease settings. For the treatment of peptide-secreting enteroendocrine cells, most...
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Triglyceride-Glucose Index Predicts Future Atherosclerotic Cardiovascular Diseases: A 16-Year Follow-up in a Prospective, Community-Dwelling Cohort Study

Moon JH, Kim Y, Oh TJ, Moon JH, Kwak SH, Park KS, Jang HC, Choi SH, Cho NH

Background: While the triglyceride-glucose (TyG) index is a measure of insulin resistance, its association with cardiovascular disease (CVD) has not been well elucidated. We evaluated the TyG index for prediction...
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Importance of continuous glucose monitoring in the treatment of diabetes mellitus

Moon SJ, Lee WY

Background: Emerging evidence suggests that controlling both glycemic variability and hemoglobin A1c is necessary to prevent complications associated with diabetes mellitus. Hence, continuous glucose monitoring (CGM) is crucial for effectively...
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Diagnosis and management of gestational diabetes mellitus

Oh TJ

Background: Gestational diabetes mellitus (GDM) is a condition characterized by hyperglycemia that is first diagnosed during pregnancy. It increases both fetal and maternal risk and is related to future metabolic...
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The evolution and future of diagnostic criteria for diabetes mellitus

Rhee EJ

Background: The diagnostic criteria for diabetes mellitus have evolved over time, taking into account new evidence. Here, the author would like to review the evolution of diagnostic criteria for diabetes...
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Triglyceride and glucose index for identifying abnormal insulin sensitivity in women with polycystic ovary syndrome

Kwon S, Heo A, Chun S

Objective We aimed to evaluate whether triglyceride and glucose (TyG) indices are useful in identifying insulin sensitivity/resistance in women with polycystic ovary syndrome (PCOS). Methods One hundred and seventy-two Korean women...
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