Obstet Gynecol Sci.  2019 Jul;62(4):249-257. 10.5468/ogs.2019.62.4.249.

Pituitary magnetic resonance imaging abnormalities in young female patients with hypogonadotropic hypogonadism

• Kang JY
• Kim SH
• Kim H
• Ki H
• Lee MH

• KMID: 2451654
• DOI: http://doi.org/10.5468/ogs.2019.62.4.249

Abstract

OBJECTIVE
To elucidate the association between clinical and laboratory characteristics and pituitary magnetic resonance imaging (MRI) abnormalities in young female patients with hypogonadotropic hypogonadism (HH).
METHODS
We retrospectively investigated a series of 74 female patients (age range, 14-42 years) with normoprolactinemic HH who underwent pituitary MRI. Pubertal milestones and hormonal features of patients with small pituitary glands (PGs) and space-occupying lesions were compared with those of patients with normal PGs.
RESULTS
The overall frequency of abnormal PGs was 35.1%, with space-occupying lesions observed in 8 patients (10.8%), and small PG observed in 18 patients (24.3%). The mean serum gonadotropin level was not different between patients with and without pituitary MRI abnormalities (P>0.05). Space-occupying lesions were not associated with low gonadotropin levels, type of amenorrhea, or presence of secondary sex characteristics. The frequency of space-occupying lesions was higher in patients with interrupted puberty (25.0%) than in patients who did not go through puberty (4.8%) or had a normal puberty (9.8%), but were not statistically significant (P>0.05). Small PG was associated with low gonadotropin levels and type of amenorrhea (P<0.05).
CONCLUSION
Clinically significant space-occupying lesions were not associated with low gonadotropin levels, type of amenorrhea, or presence of secondary sex characteristics. However, the frequency of space-occupying lesions was higher in patients with interrupted puberty than in patients who did not go through puberty or who with normal puberty.

Keyword

Hypogonadotropic hypogonadism; Amenorrhea; Delayed puberty; Magnetic resonance imaging

MeSH Terms

Adolescent
Amenorrhea
Female*
Gonadotropins
Humans
Hypogonadism*
Magnetic Resonance Imaging*
Pituitary Gland
Puberty
Puberty, Delayed
Retrospective Studies
Sex Characteristics
Gonadotropins

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