Korean J Urol.
1991 Aug;32(4):637-641.
Pulsatile GnRH therapy in male patients with hypogonadotropic hypogonadism
- Affiliations
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- 1Department of Urology, Yonsei University, College of Medicine, Seoul, Korea.
- 2Department of Obstetrics and Gynecology, Yonsei University, College of Medicine, Seoul, Korea.
- 3Department of Internal Medicine, Yonsei University, College of Medicine, Seoul, Korea.
Abstract
- The effects of pulsatile GnRH therapy have been studied for the treatment of different forms of hypogonadotropic hypogonadism, including idiopathic hypogonadotropic hypogonadism and hypogonadism developed as a result of treatment with combination of surgery and irradiation for pituitary or hypothalamic tumor. GnRH was administered subcutaneously in a dose of 10ug every 2 hours with the pulsatile infusion pump. With GnRH therapy, all patients improved secretion of LH, FSH and testosterone. Testicular volumes increased. Spermatogenesis was induced in 4 patients. Pulsatile GnRH therapy is an effective treatment for idiopathic hypogonadotropic hypogonadism and can have a role in hypogonadism previously treated with combination of surgery and irradiation for pituitary or hypothalamic tumor.
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