Int J Thyroidol.  2018 Nov;11(2):61-70. 10.11106/ijt.2018.11.2.61.

Adverse Events of Tyrosine Kinase Inhibitors in Patients with Advanced Thyroid Cancer

• Kim MJ
• Park YJ

• KMID: 2448972
• DOI: http://doi.org/10.11106/ijt.2018.11.2.61

Abstract

Tyrosine kinase inhibitors (TKIs) are widely used for the treatment of advanced radioiodine-refractory thyroid cancer. Although the previous studies including large-scale randomized controlled trials have demonstrated the effects of TKIs in advanced thyroid cancers, it has been found that most patients experienced adverse events (AEs). Unlike other cancers, even patients with advanced thyroid cancers are often asymptomatic. Rather, TKI use can make patients suffer adverse events. Therefore, the use of TKI should be decided after the full consideration of AEs as well as its efficacies. While using TKI, AEs should be monitored, evaluated, and managed appropriately, if AEs develop. In this review, the occurrence, evaluation, and management of AEs of sorafenib, lenvatinib, and vandetanib will be described, which TKIs are most commonly used for the treatment of advanced thyroid cancer. Some suggestions for the management of AEs in the real life are also provided.

Keyword

Adverse events; Lenvatinib; Sorafenib; Thyroid cancer; Vandetanib

MeSH Terms

Humans
Protein-Tyrosine Kinases*
Thyroid Gland*
Thyroid Neoplasms*
Tyrosine*
Protein-Tyrosine Kinases
Tyrosine

Figure

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  Fig. 1 Adverse event record (Reprint with permission from Reference 20. Copyright 2013 Endocrine Society).

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