Int J Thyroidol.  2018 Nov;11(2):82-87. 10.11106/ijt.2018.11.2.82.

Skin-Related Toxicity of Tyrosine Kinase Inhibitor in Thyroid Cancer

• Lim DJ

• KMID: 2448976
• DOI: http://doi.org/10.11106/ijt.2018.11.2.82

Abstract

Skin-related toxicity is one of the most important adverse events from multi-target tyrosine kinase inhibitor (MTKI) to treat radioiodine refractory thyroid cancer. As hand foot skin reaction can limit quality of life and therapeutic effectiveness, it is essential to cope with a variety of severity of skin-related toxicity induced by MTKI. Herein, we will discuss two representative cases of skin-related toxicities which were managed by discontinuation/reduction of therapeutic doses of MTKI and were treated by proper medication in thyroid cancer patients with distant metastasis.

Keyword

Thyroid neoplasms; Protein kinase inhibitors; Hand-foot syndrome

MeSH Terms

Foot
Hand
Hand-Foot Syndrome
Humans
Neoplasm Metastasis
Protein Kinase Inhibitors
Protein-Tyrosine Kinases*
Quality of Life
Skin
Thyroid Gland*
Thyroid Neoplasms*
Tyrosine*
Protein Kinase Inhibitors
Protein-Tyrosine Kinases
Tyrosine