Nutr Res Pract.  2018 Oct;12(5):378-386. 10.4162/nrp.2018.12.5.378.

Corni Fructus attenuates testosterone-induced benign prostatic hyperplasia by suppressing 5α-reductase and androgen receptor expression in rats

Affiliations
  • 1Anti-Aging Research Center, Dongeui University, Busan 47340, Korea. choiyh@deu.ac.kr
  • 2Open Laboratory for Muscular and Skeletal Disease and Department of Biochemistry, Dongeui University College of Korean Medicine, 42 San, Yangjungdong, Busan 47227, Korea.
  • 3Department of Anatomy, Kosin University College of Medicine, Busan 49267, Korea.
  • 4Gurye Sansooyu Farming Association Corporation, Jeonnam 57602, Korea.
  • 5Gurye-gun Agricultural Center, Jeonnam 57660, Korea.
  • 6Department of Anatomy, Dongeui University College of Korean Medicine, Busan 47227, Korea.
  • 7Laboratory of Immunobiology, Department of Marine Life Sciences, Jeju National University, Jeju 63243, Korea.
  • 8Department of Molecular Biology, College of Natural Sciences, Dongeui University, Busan 47340, Korea.

Abstract

BACKGROUND/OBJECTIVES
Benign prostatic hypertrophy (BPH) is a major cause of abnormal overgrowth of the prostate mainly in the elderly. Corni Fructus has been reported to be effective in the prevention and treatment of various diseases because of its strong antioxidant effect, but its efficacy against BPH is not yet known. This study was designed to evaluate the therapeutic efficacy of Corni Fructus water extract (CF) in testosterone-induced BPH rats.
MATERIALS/METHODS
To induce BPH, rats were intraperitoneal injected with testosterone propionate (TP). Rats in the treatment group were orally administered with CF with TP injection, and finasteride, which is a selective inhibitor of 5α-reductase type 2, was used as a positive control.
RESULTS
Our results showed that the increased prostate weight and histopathological changes in BPH model rats were suppressed by CF treatment. CF, similar to the finasteride-treated group, decreased the levels of testosterone and dihydrotestosterone by TP treatment in the serum, and it also reduced 5α-reductase expression and concentration in prostate tissue and serum, respectively. In addition, CF significantly blocked the expression of the androgen receptor (AR), AR co-activators, and proliferating cell nuclear antigen in BPH rats, and this blocking was associated with a decrease in prostate-specific antigen levels in serum and prostate tissue.
CONCLUSIONS
These results suggest that CF may weaken the BPH status through the inactivation of at least 5α-reductase and AR activity and may be useful for the clinical treatment of BPH.

Keyword

Benign prostatic hyperplasia; corni fructus; dihydrotestosterone; androgen receptor; prostate-specific antigen

MeSH Terms

Aged
Animals
Antioxidants
Cornus*
Dihydrotestosterone
Finasteride
Humans
Proliferating Cell Nuclear Antigen
Prostate
Prostate-Specific Antigen
Prostatic Hyperplasia*
Rats*
Receptors, Androgen*
Testosterone
Testosterone Propionate
Water
Antioxidants
Dihydrotestosterone
Finasteride
Proliferating Cell Nuclear Antigen
Prostate-Specific Antigen
Receptors, Androgen
Testosterone
Testosterone Propionate
Water
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