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Role of Androgen Receptor in Prostate Cancer: A Review

Fujita K, Nonomura N

Androgen receptor (AR) is a steroid receptor transcriptional factor for testosterone and dihydrotestosterone consisting of four main domains, the N-terminal domain, DNA-binding domain, hinge region, and ligand-binding domain. AR plays...
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Finasteride and Erectile Dysfunction in Patients with Benign Prostatic Hyperplasia or Male Androgenetic Alopecia

Shin YS, Karna KK, Choi BR, Park JK

Finasteride is primarily used to treat benign prostatic hyperplasia (BPH) and male androgenetic alopecia (MAA). Five-alpha reductase inhibitors (5α-RIs) could induce male sexual dysfunction due to their effects on testosterone...
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Clinical Course of the Benign Prostate Hyplasia Patients during the Intermittent Use of 5-Alpha Reductase Inhibitors

Choi K, Kim B, Cho IC, Min SK

PURPOSE: 5-Alpha reductase inhibitors (5ARI), inhibit the conversion of testosterone to dihydrotestosterone, which is essential in prostate hyperplasia, and decreases the prostate volume directly. On the other hand, 5ARI have...
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RE-ORGA, a Korean Herb Extract, Can Prevent Hair Loss Induced by Dihydrotestosterone in Human Dermal Papilla Cells

Kang MG, Park D, Han HY, Shim H, Hong Y, Moon J, Yoon S, Kwon B

BACKGROUND: Androgenic alopecia (AGA) is the most common type of hair loss. It is likely inherited genetically and is promoted by dihydrotestosterone. 5α-reductase has been proven a good target through...
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Inhibitory effects of Pycnogenol®, a pine bark extract, in a rat model of testosterone propionate-induced benign prostatic hyperplasia

Ko JW, Park SW, Shin NR, Kim WI, Kim JC, Shin IS, Shin DH

Benign prostate hyperplasia (BPH) is a male reproductive disease that has gained increasing importance in recent years. The present study investigated whether Pycnogenol® (PYC), a standardized French maritime pine bark...
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Corni Fructus attenuates testosterone-induced benign prostatic hyperplasia by suppressing 5α-reductase and androgen receptor expression in rats

Hwangbo H, Kwon DH, Choi EO, Kim MY, Ahn KI, Ji SY, Kim JS, Kim KI, Park NJ, Kim BH, Kim GY, Hong SH, Park C, Jeong JS, Choi YH

BACKGROUND/OBJECTIVES: Benign prostatic hypertrophy (BPH) is a major cause of abnormal overgrowth of the prostate mainly in the elderly. Corni Fructus has been reported to be effective in the prevention...
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Corn silk extract improves benign prostatic hyperplasia in experimental rat model

Kim SR, Ha AW, Choi HJ, Kim SL, Kang HJ, Kim MH, Kim WK

BACKGROUND/OBJECTIVES: This study was conducted to investigate the effect of a corn silk extract on improving benign prostatic hyperplasia (BPH). MATERIALS/METHODS: The experimental animals, 6-week-old male Wistar rats, were divided into...
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Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells

Shin S, Kim K, Lee MJ, Lee J, Choi S, Kim KS, Ko JM, Han H, Kim SY, Youn HJ, Ahn KJ, An IS, An S, Cha HJ

BACKGROUND: Dihydrotestosterone (DHT) induces androgenic alopecia by shortening the hair follicle growth phase, resulting in hair loss. We previously demonstrated how changes in the microRNA (miRNA) expression profile influenced DHT-mediated...
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The Effect of Two Weeks of Treatment with Dutasteride on Bleeding after Transurethral Resection of the Prostate

Kim KS, Jeong WS, Park SY, Kim YT, Moon HS

PURPOSE: Dutasteride affects the prostate by reducing intraprostatic dihydrotestosterone and prostate tissue vascularity. We evaluated the effect of pretreatment with dutasteride for two weeks on perioperative and postoperative bleeding during...
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Positive Role of Dutasteride in the Treatment of Localized Prostate Cancer

Kim JH

Dual inhibition of both 5AR1 and 5AR2 by dutasteride provides greater and more consistent inhibition of the conversion of testosterone to dihydrotestosterone (DHT) than selective inhibition of 5AR2 alone. Beyond...
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The association of 5-alpha reductase type 2 (SRD5A2) gene polymorphisms with prostate cancer in a Korean population

Choi SY, Kim HJ, Cheong HS, Myung SC

PURPOSE: Steroid 5-alpha reductase type 2 (SRD5A2) modifies testosterone to dihydrotestosterone (DHT) in the prostate. Single-nucleotide polymorphisms (SNPs) of the SRD5A2 gene might affect DHT. We sought to understand the...
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Resveratrol Inhibits IL-6-Induced Transcriptional Activity of AR and STAT3 in Human Prostate Cancer LNCaP-FGC Cells

Lee MH, Kundu JK, Keum YS, Cho YY, Surh YJ, Choi BY

Prostate cancer is the most frequently diagnosed cancer. Although prostate tumors respond to androgen ablation therapy at an early stage, they often acquire the potential of androgen-independent growth. Elevated transcriptional...
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The Anti-Inflammatory Effects of a New Herbal Formula (WSY-1075) in a Nonbacterial Prostatitis Rat Model

Yoon BI, Bae WJ, Kim SJ, Kim HS, Ha US, Sohn DW, Hwang SY, Kim SW

  • KMID: 2320843
  • World J Mens Health.
  • 2013 Aug;31(2):150-156.
PURPOSE: The aim of this study was to investigate the anti-inflammatory effects of a new herbal formula (WSY-1075) in a nonbacterial prostatitis rat model. MATERIALS AND METHODS: Prostatitis was induced in...
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Effect of Phellius linteus water extract on benign prostatic hyperplasia

Kim YN, Kim MS, Chun SS, Choi JH

  • KMID: 2313666
  • Nutr Res Pract.
  • 2013 Jun;7(3):172-177.
Benign prostatic hyperplasia (BPH) is one of the most common diseases among elderly men. As the old-age population is increasing recently, it is to our interest to observe the growing...
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Hair characteristics and androgenetic alopecia in Koreans

Choi GS

The scalp hair is composed of one hundred thousand of hairs. Each hair goes through the three phases of the hair cycle, which causes the hair to turn from an...
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5alpha-Reductase

Park JS, Cho MC, Paick JS

Androgen acts via the androgen receptor and can play a critical role in the development and growth of the prostate and the pathophysiology of prostatic diseases. Testosterone is the most...
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Computerized Measurement on Angular Parameters for Hallux Valgus: Comparison of 100% and 150% Magnified Digital Radiography

Sung IH, Lee DY, Sung CH, Seo WY

  • KMID: 1811629
  • J Korean Foot Ankle Soc.
  • 2012 Mar;16(1):53-57.
PURPOSE: To study computerized measurements of angular parameters on 100% and 150% resized digital radiography of hallux valgus deformity. MATERIALS AND METHODS: 30 digital radiography of standing foot anteroposterior view of...
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In Vitro Evaluation Method to Monitor Pathogenic Acne Vulgaris by Culturing Keratinocytes with Sebocytes

Park MK, Park KY, Kim BJ, Kim MN, Kim JH, Koh HJ, Park WS

  • KMID: 1447388
  • Korean J Dermatol.
  • 2011 Dec;49(12):1057-1063.
BACKGROUND: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. Keratinocytes and sebocytes are the two major cell types involved in the induction of acne within the pilosebaceous...
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Treatment of Hallux Valgus with Distal Chevron Metatarsal Osteotomy

Ahn JH, Choy WS, Kim HY, Lee DH, Bae KW

  • KMID: 1469352
  • J Korean Foot Ankle Soc.
  • 2009 Dec;13(2):124-128.
PURPOSE: The authors intended to analyze the operative results of mild to moderate hallux valgus treated with distal chevron metatarsal osteotomy. MATERIALS AND METHODS: Twenty six feet of twenty three patients...
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Effect of dihydrotestosterone on mouse embryonic stem cells exposed to H(2)O(2)-induced oxidative stress

Lee MN, Lee SH, Lee MY, Kim YH, Park JH, Ryu JM, Yun SP, Lee YJ, Kim MO, Park K, Han HJ

Oxidative stresses induced by reactive oxygen species (ROS) have been shown to be involved in several physiological and pathophysiological processes, such as cell proliferation and differentiation. Steroid hormones can protect...
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