Korean J Urol.  1989 Dec;30(6):856-859.

The Diagnostic Value of the HCG Stimulation Test for 5 alpha-reductase Deficiency in Children

Affiliations
  • 1Department of Urology, Yonsei University, College of Medicine, Seoul, Korea.

Abstract

We evaluated 15 children with hypospadias or micropenis for the presence of 5 a-reductase deficiency. Serum testosterone and dihydrotestosterone(DHT) concentrations were measured before and 3 days after HCG stimulation. Also, testosterone : dihydrotestosterone (T:DHT) conversion ratios were calculated in each children in order to determine the activity of 5 a-reductase. DHT was abnormally low in 14 children, and T:DHT conversion ratios were abnormal in 12 children in basal state. But T:DHT conversion ratios were abnormal in 2 children after HCG stimulation. In children, 5 a-reductase deficiency can not be diagnosed low serum DHT or abnormal T:DHT conversion ratio, but diagnosed abnormally high T:DHT conversion ratio after HCG stimulation.

Keyword

HCG stimulation test; 5 alpha-reductase deficiency

MeSH Terms

Child*
Cholestenone 5 alpha-Reductase*
Dihydrotestosterone
Female
Humans
Hypospadias
Male
Testosterone
Cholestenone 5 alpha-Reductase
Dihydrotestosterone
Testosterone
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