A Clinical Investigation for Effect of Chlormadinone acetate(Prostal

Kwon, Sung Won

Abstract

The hypertrophied prostate is the most common cause of infravesical obstrcutions, in the male patients with 50 years old or above. Though the cause of benign prostatic. hypertrophy has not clearly identified yet, recently it has been clarified that androgen, especially dihydrotestosterone, may play a great role in the benign prostatic hypertrophy. The author carried out to investigate the effect of Chlormadinone acetate-potent oral synthetic anti-androgen agent on prostatic volume and obstructive urinary symptoms induced by hypertrophied pro. static gland. The following results were obtained; 1. 23 patients were studied :19 patients with benign prostatic hypertrophy and 4 patients with benign prostatic hypertrophy and 4 patients with prostatic cancer. The mean age of patients was 72 years old. 2. The mean prostatic volume was markedly decreased from 58.7+/-2.94cc before treatment to 23.6+/-1.06cc 16 weeks after treatment. 3. Obstructive urinary symptoms, residual urine and nocturnal frequency were improved after treatment. 4. Judging from the fracts mentioned above, it may be believed that Chlormadinone acetate increase the effect of transurethral resection and prevent the rehypertrophied prostate after transurethral resection of prostate.