Tuberc Respir Dis.
2009 Jul;67(1):47-51.
Secondary Adrenal Insufficiency Associated with Megestrol Acetate in a Patient with Lung Cancer
- Affiliations
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- 1Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. sypark1011@hotmail.com
Abstract
- Loss of appetite is an important factor in the quality of life for advanced cancer patients. Megestrol acetate is used to stimulate appetite, but it can cause suppression of the pituitary adrenal axis due to the affinity of the glucocorticoid receptor. Adrenal insufficiency is a life threatening disorder if left, untreated, but the initial clinical symptoms of the patients are vague. Awareness of the glucocorticoid-like activity of megestrol acetate and its side effects are important for the diagnosis of adrenal insufficiency. We present a case of secondary adrenal insufficiency associated with megestrol acetate in a patient with lung cancer.
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