Korean J Urol.  2006 Dec;47(12):1289-1293. 10.4111/kju.2006.47.12.1289.

The Antihyperplastic Effect of Oral Catechin Ingestion in a Rat Model of Benign Prostatic Hyperplasia

Affiliations
  • 1Department of Urology, The Catholic University of Korea, Seoul, Korea. cyh0831@catholic. ac.kr

Abstract

PURPOSE
Benign prostatic hyperplasia (BPH) is one of the common diseases in elderly men. Recently, the old-aged population has increased, with the interest in the clinical importance of BPH ever growing. Catechin, an extract of green tea, has the effect of the 5-alpha reductase inhibitor. Typically, BPH has been shown to be influenced by 5-alpha reductase. Therefore, the relationship between BPH and catechin was evaluated.
MATERIALS AND METHODS
An experimental prostatic hyperplasia was induced in male Wistar rats by the administration of testosterone propionate, 3mg/kg sc, for 4 weeks. The Wistar rats were divided into four experimental groups: the control, BPH-induced, oral finasteride ingestion and oral catechin ingestion groups. After 4 weeks, the prostates were removed, and analyzed for their prostatic weight and histological examination.
RESULTS
The prostate weights were measured in each group, and found to be 330.0+/-40.7, 970.0+/-1.1, 358.0+/-39.9 and 415.0+/-45.3mg in the control, BPH-induced, oral finasteride ingestion and oral catechin ingestion groups, respectively. The oral finasteride and catechin ingestion groups showed statistically significant decreases in their prostatic weights compared with the BPH-induced group (p<0.05), but with no significant difference between the oral finasteride and catechin ingestion groups (p>0.05). Histologically injected testosterone lead to prostatic hyperplasia in rats, but oral catechin ingestion decreased this change.
CONCLUSIONS
These results suggest that catechin may be effective in BPH, and the consumption of green tea may be effective in preventing BPH.

Keyword

Benign prostatic hyperplasia; Catechin; Testosterone; 5 alpha-reductase

MeSH Terms

Aged
Animals
Catechin*
Cholestenone 5 alpha-Reductase
Eating*
Finasteride
Humans
Male
Models, Animal*
Oxidoreductases
Prostate
Prostatic Hyperplasia*
Rats*
Rats, Wistar
Tea
Testosterone
Testosterone Propionate
Weights and Measures
Catechin
Cholestenone 5 alpha-Reductase
Finasteride
Oxidoreductases
Tea
Testosterone
Testosterone Propionate
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