Nat Prod Sci.  2019 Sep;25(3):200-207. 10.20307/nps.2019.25.3.200.

Albizzia julibrissin Suppresses Testosterone-induced Benign Prostatic Hyperplasia by Regulating 5α-Reductase Type 2 – Androgen Receptor Pathway

Affiliations
  • 1Department of Veterinary Medicine & Institute of Veterinary Science, Chungnam National University, Daejeon, Republic of Korea. jyjung@cnu.ac.kr
  • 2Center for Vascular Research, Institute for Basic Science (IBS), Daejeon, Republic of Korea.
  • 3Samsung Biomedical Research Institute, Seoul, Republic of Korea.
  • 4Department of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.

Abstract

Albizzia julibrissin (AJ) is an herbal medicine that shows low toxicity, promotes promoting blood circulation and mitigates the inflammation and has mild side effects. Benign prostate hyperplasia (BPH) is one of the most common diseases that occurs in older males and often results in lower urinary tract symptoms. This study was conducted to evaluate the protective effect of AJ against BPH using LNCaP cells and Sprague Dawley rats treated with testosterone. Treatment with AJ extract reduced the expression of androgen receptor (AR) and prostate-specific antigen (PSA) in vitro. In vivo, rats were divided into 6 groups: 1 (Normal Control); 2 (Testosterone propionate (TP) alone); 3 (TP + finasteride); 4 (TP + AJ 10 mg/kg); 5 (TP + AJ 50 mg/kg); 6 (TP + AJ 300 mg/kg). The groups treated with AJ showed reduced the relative prostate weights and BPH-related proteins were altered, with decreased AR, PSA and proliferating cell nuclear antigen (PCNA) observed by western blot. Histopathological analysis revealed the therapeutic effect of AJ, with a decreased thickness of epithelial cells and reduced level of PCNA and 5α-reductase type 2. These results suggest that AJ extract could ameliorate testosterone-induced benign prostatic hyperplasia.

Keyword

Benign prostate hyperplasia; Albizzia julibrissin; 5α-reductase type 2; androgen receptor; proliferating cell nuclear antigen

MeSH Terms

Albizzia*
Animals
Blood Circulation
Blotting, Western
Diethylpropion
Epithelial Cells
Herbal Medicine
Humans
Hyperplasia
In Vitro Techniques
Inflammation
Lower Urinary Tract Symptoms
Male
Proliferating Cell Nuclear Antigen
Prostate
Prostate-Specific Antigen
Prostatic Hyperplasia*
Rats
Rats, Sprague-Dawley
Receptors, Androgen*
Testosterone
Weights and Measures
Diethylpropion
Proliferating Cell Nuclear Antigen
Prostate-Specific Antigen
Receptors, Androgen
Testosterone
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