Korean J Pediatr Infect Dis.  2006 Nov;13(2):155-162. 10.14776/kjpid.2006.13.2.155.

Change of Antimicrobial Use Density According to Application of Computerized Management Program for Restriction of Antimicrobials Use in a University Hospital

• Lee BY
• Kim CS
• Ryu SY
• Kwon KY
• Lim JG
• Lim TJ
• Min BW
• Ryoo NH
• Cha SD

• KMID: 2439983
• DOI: http://doi.org/10.14776/kjpid.2006.13.2.155

Abstract

PURPOSE
Appropriate use of antimicrobials is an essential factor to treat infectious diseases and prevent acquisition of antimicrobial resistant pathogens. This study was undertaken to search that application of computerized management program for restriction of antimicrobials use in a hospital is helpful to decrease antimicrobial use density.
METHODS
Antibiotics utilization committee decided to restrict the use of 16 antimicrobials(14 expensive drugs having fear of drug resistance by pathogens and additional two drugs with inappropriate using tendency). Retrospective evaluation of antimicrobial user numbers between May and July of 2004 and 2005(study group) was conducted to compare with previous use density during same period of 2002 and 2003(control group).
RESULTS
Inpatients number of control group(823.5±37.1 persons) was more than study group(809.2±39.3 persons, P < 0.001), but, outpatients number and hospitalized duration were equal in two groups. Antimicrobial user number/100 inpatients per day of glycopeptides and antifungal agents was equal in two groups, and study group was significantly higher density than control group in the use of carbapenems, piperacillin-tazobactam and quinolones(P < 0.001). But study group was significantly lower density than control group in the use of drugs with inappropriately using tendency and expensive cephalosporins having broad antimicrobial spectrum(P < 0.001).
CONCLUSION
Application of computerized management program for restriction of antimicrobials use in a hospital is effective to decrease the use density of antimicrobials with inappropriately using tendency, but it is an insufficient measures for the restricted use of other antimicrobials on the whole.

Keyword

Antimicrobials; Restriction; Computerized; Management program

MeSH Terms

Anti-Bacterial Agents
Antifungal Agents
Carbapenems
Cephalosporins
Communicable Diseases
Drug Resistance
Glycopeptides
Humans
Inpatients
Outpatients
Retrospective Studies
Anti-Bacterial Agents
Antifungal Agents
Carbapenems
Cephalosporins
Glycopeptides