Electrolyte Blood Press.  2007 Dec;5(2):111-115. 10.5049/EBP.2007.5.2.111.

Antimicrobial-induced Electrolyte and Acid-Base Disturbances

• Kim YW

• KMID: 2052293
• DOI: http://doi.org/10.5049/EBP.2007.5.2.111

Abstract

Antimicrobials are one of the most widely prescribed classes of therapeutic agents. Although adverse effects of antimicrobials are generally minimal and reversible, serious sequelae can sometimes remain, such as unusual forms of renal failure, acid base disturbance and electrolyte abnormalities. Many antimicrobials, especially vancomycin or aminoglycosides, are associated with development of acute renal failure caused by acute tubular necrosis, allergic acute interstitial nephritis, or vasculitis. Besides, some antimicrobial agents can cause serious fluid and electrolyte imbalance. To prevent these serious consequences, early recognition and correction of their harmful renal and electrolyte effects are required.

MeSH Terms

Acute Kidney Injury
Aminoglycosides
Anti-Infective Agents
Necrosis
Nephritis, Interstitial
Renal Insufficiency
Vancomycin
Vasculitis
Aminoglycosides
Anti-Infective Agents
Vancomycin