Genomics Inform.  2018 Dec;16(4):e25. 10.5808/GI.2018.16.4.e25.

Circulating HOTAIR LncRNA Is Potentially Up-regulated in Coronary Artery Disease

• Avazpour N
• Hajjari M
• Yazdankhah S
• Sahni A
• Foroughmand AM

• KMID: 2439215
• DOI: http://doi.org/10.5808/GI.2018.16.4.e25

Abstract

Coronary artery disease (CAD) is one of the leading causes of death and disability all around the world. Recent studies have revealed that aberrantly regulated long non-coding RNA (lncRNA) as one of the main classes of cellular transcript plays a key regulatory role in transcriptional and epigenetic pathways. Recent reports have demonstrated that circulating lncRNAs in the blood can be potential biomarkers for CAD. HOTAIR is one of the most cited lncRNAs with a critical role in the initiation and progression of the gene expression regulation. Recent research on the role of the HOTAIR in cardiovascular disease lays the basis for the development of new studies considering this lncRNA as a potential biomarker and therapeutic target in CAD. In this study, we aimed to compare the expression of HOTAIR lncRNA in the blood samples of patients with CAD and control samples. The expression level was examined by semi-quantitative reverse transcriptase polymerase chain reaction technique. Our data shows that expression of HOTAIR is up-regulated in blood samples of patients with CAD.

Keyword

coronary artery disease; gene expression; HOTAIR; long noncoding RNA

MeSH Terms

Biomarkers
Cardiovascular Diseases
Cause of Death
Coronary Artery Disease*
Coronary Vessels*
Epigenomics
Gene Expression
Gene Expression Regulation
Humans
Reverse Transcriptase Polymerase Chain Reaction
RNA, Long Noncoding*
Biomarkers
RNA, Long Noncoding