Pediatr Infect Vaccine.  2018 Apr;25(1):50-53. 10.14776/piv.2018.25.1.50.

Panton-Valentine Leukocidin Positive Methicillin-Susceptible Staphylococcus aureus: A Case Report of Two Pediatric Patients with Thrombotic Complications

• Ng DC
• Anand LA
• Khiu FL
• Tan KK

• KMID: 2438754
• DOI: http://doi.org/10.14776/piv.2018.25.1.50

Abstract

Staphylococcus aureus is a well-recognized human pathogen that causes a wide range of infections as a result of its extensive virulence factors. One of these factors is Panton-Valentine leukocidin (PVL), a potent pore-forming cytotoxin that has been linked to invasive S. aureus infections. PVL is one of the important virulence factors for S. aureus and has been largely recognized as one of the markers for community-acquired methicillin-resistant S. aureus. However, the presence of PVL in methicillin-susceptible S. aureus infections is not widely reported in the literature. Thrombotic sequelae of S. aureus infections associated with PVL expression are uncommon in children. We hereby report two children with thrombotic complications associated with PVL-producing methicillin-susceptible S. aureus. Both patients responded well to antibiotic and anticoagulant therapies, and survived without any long-term sequelae.

Keyword

Panton-Valentine leukocidin; Staphylococcus aureus; Child

MeSH Terms

Child
Humans
Leukocidins*
Methicillin Resistance
Staphylococcus aureus*
Staphylococcus*
Virulence Factors
Leukocidins
Virulence Factors

Figure

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  Fig. 1. Filling defect seen within the enlarged right cavernous sinus (arrow) with proptosis of right globe for patient 1.

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  Fig. 2. Ultrasound Doppler at transverse section over right common femoral vein (RCFV) and right popliteal vein (R POP V) showed an echogenic thrombus within with no Doppler signal for patient 2. Abbreviation: WC, with compression.

Reference

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