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Pediatr Infect Vaccine.  2018 Aug;25(2):107-112. 10.14776/piv.2018.25.e6.

Recurrent Familial Furunculosis Associated with Panton-Valentine Leukocidin-Positive Methicillin-Susceptible Staphylococcus aureus ST1

Affiliations
  • 1Department of Internal Medicine, Kosin University College of Medicine, Busan, the Republic of Korea.
  • 2Department of Internal Medicine, Kosin University Gospel Hospital, Busan, the Republic of Korea. aiteite1@naver.com
  • 3Department of Dental Hygiene, College of Health and Welfare, Silla University, Busan, the Republic of Korea.
  • 4Department of Laboratory Medicine, Kosin University College of Medicine, Busan, the Republic of Korea.
  • 5Department of Pediatrics, Kosin University College of Medicine, Busan, the Republic of Korea.

Abstract

Staphylococcus aureus is now a major community-acquired pathogen worldwide, notably associated with skin and soft tissue infections. Staphylococci are present in the form of colonizers or environmental contaminants at home and increase the risk of recurrent infection. We are describing recurrent familial furunculosis caused by Panton-Valentine Leukocidin-positive methicillin susceptible S. aureus ST1 in Korea. An infant, his father and mother had furunculosis due to methicillin-sensitive S. aureus (MSSA) infection with identical susceptibility patterns. ST1 accounted for all 3 isolates and they were confirmed of having agr group I. Both sec and seh were detected in all isolates using polymerase chain reaction (PCR) assays, and all isolates contained Panton-Valentine leukocidin (PVL) genes. Risk factors for the household spread of S. aureus include skin conditions and close physical contact among household members. The relationship between S. aureus colonization of household contacts and the occurrence of S. aureus infection should be studied into more detail.

Keyword

Staphylococcus aureus; Furunculosis; Family characteristics; Panton-Valentine leukocidin

MeSH Terms

Colon
Family Characteristics
Fathers
Furunculosis*
Humans
Infant
Korea
Leukocidins
Methicillin
Mothers
Polymerase Chain Reaction
Risk Factors
Skin
Soft Tissue Infections
Staphylococcus aureus*
Staphylococcus*
Leukocidins
Methicillin
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