Pediatr Infect Vaccine.  2018 Aug;25(2):107-112. 10.14776/piv.2018.25.e6.

Recurrent Familial Furunculosis Associated with Panton-Valentine Leukocidin-Positive Methicillin-Susceptible Staphylococcus aureus ST1

• Lee JY
• Park JY
• Bae IK
• Jeong S
• Park JH
• Jin S

• KMID: 2418543
• DOI: http://doi.org/10.14776/piv.2018.25.e6

Abstract

Staphylococcus aureus is now a major community-acquired pathogen worldwide, notably associated with skin and soft tissue infections. Staphylococci are present in the form of colonizers or environmental contaminants at home and increase the risk of recurrent infection. We are describing recurrent familial furunculosis caused by Panton-Valentine Leukocidin-positive methicillin susceptible S. aureus ST1 in Korea. An infant, his father and mother had furunculosis due to methicillin-sensitive S. aureus (MSSA) infection with identical susceptibility patterns. ST1 accounted for all 3 isolates and they were confirmed of having agr group I. Both sec and seh were detected in all isolates using polymerase chain reaction (PCR) assays, and all isolates contained Panton-Valentine leukocidin (PVL) genes. Risk factors for the household spread of S. aureus include skin conditions and close physical contact among household members. The relationship between S. aureus colonization of household contacts and the occurrence of S. aureus infection should be studied into more detail.

Keyword

Staphylococcus aureus; Furunculosis; Family characteristics; Panton-Valentine leukocidin

MeSH Terms

Colon
Family Characteristics
Fathers
Furunculosis*
Humans
Infant
Korea
Leukocidins
Methicillin
Mothers
Polymerase Chain Reaction
Risk Factors
Skin
Soft Tissue Infections
Staphylococcus aureus*
Staphylococcus*
Leukocidins
Methicillin

Figure

• 

  Fig. 1 A palpable mass of a 16-month old boy (patient 1). A red tender mass in the left axilla is about 8 cm in size.

• 

  Fig. 2 Left axillary mass in a 16-month old boy (patient 1). Transverse sonography shows a heterogeneous hypoechoic mass (arrow) with internal septations.

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