Korean J Clin Microbiol.  2008 Oct;11(2):129-131. 10.5145/KJCM.2008.11.2.129.

A Fatal Case of Infective Endocarditis Caused by Community-Associated Methicillin-Resistant Staphylococcus aureus ST72 in Korea

  • 1Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea. drjwchung@cau.ac.kr


The advent of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has been a worldwide threat to public health for the past decade. We report a fatal case of infective endocarditis caused by a non-USA300, Panton-Valentine leukocidin toxin-negative CA-MRSA clone. This is a serious case of CA-MRSA infection caused by a sequence type (ST) 72 clone, which is one of the common CA-MRSA clones circulating in Korea where serious CA-MRSA infections have been rare.


Staphylococcus aureus; Endocarditis; Methicillin Resistant

MeSH Terms

Bacterial Toxins
Clone Cells
Methicillin Resistance
Methicillin-Resistant Staphylococcus aureus
Public Health
Staphylococcus aureus
Bacterial Toxins


  • Fig. 1. Molecular detection of type IV SCCmec and PVL virulence gene. PCR amplification with specific primers shows the presence of mecA and type IV SCCmec in the CA-MRSA isolate. However, PCR for detection of the PVL gene shows the absence of PVL gene in the isolate.



1. Diederen BM and Kluytmans JA. The emergence of infections with community-associated methicillin resistant Staphylococcus aureus. J Infect. 2006; 52:157–68.
2. Zetola N, Francis JS, Nuermberger EL, Bishai WR. Community-acquired methicillin-resistant Staphylococcus aureus: an emerging threat. Lancet Infect Dis. 2005; 5:275–86.
3. Kim ES, Song JS, Lee HJ, Choe PG, Park KH, Cho JH, et al. A survey of community-associated methicillin-resistant Staphylococcus aureus in Korea. J Antimicrob Chemother. 2007; 60:1108–14.
4. Strommenger B, Kettlitz C, Werner G, Witte W. Multiplex PCR assay for simultaneous detection of nine clinically relevant antibiotic resistance genes in Staphylococcus aureus. J Clin Microbiol. 2003; 41:4089–94.
5. Oliveira DC and de Lencastre H. Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2002; 46:2155–61.
6. Lina G, Piémont Y, Godail-Gamot F, Bes M, Peter MO, Gauduchon V, et al. Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. Clin Infect Dis. 1999; 29:1128–32.
7. Enright MC, Day NP, Davies CE, Peacock SJ, Spratt BG. Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J Clin Microbiol. 2000; 38:1008–15.
8. Ko KS, Lee JY, Baek JY, Peck KR, Rhee JY, Kwon KT, et al. Characterization of Staphylococcus aureus nasal carriage from children attending an outpatient clinic in Seoul, Korea. Microb Drug Resist. 2008; 14:37–44.
9. Bahrain M, Vasiliades M, Wolff M, Younus F. Five cases of bacterial endocarditis after furunculosis and the ongoing saga of community-acquired methicillin-resistant Staphylococcus aureus infections. Scand J Infect Dis. 2006; 38:702–7.
10. Tsigrelis C, Armstrong MD, Vlahakis NE, Batsis JA, Baddour LM. Infective endocarditis due to community-associated methicillin-resistant Staphylococcus aureus in injection drug users may be associated with Panton-Valentine leukocidin-negative strains. Scand J Infect Dis. 2007; 39:299–302.
11. Millar BC, Prendergast BD, Moore JE. Community-associated MRSA (CA-MRSA): an emerging pathogen in infective endocarditis. J Antimicrob Chemother. 2008; 61:1–7.
Full Text Links
  • KJCM
export Copy
  • Twitter
  • Facebook
Similar articles
Copyright © 2023 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr