Nucl Med Mol Imaging.
2018 Dec;52(6):407-419. 10.1007/s13139-018-0550-9.
Brain Theranostics and Radiotheranostics: Exosomes and Graphenes In Vivo as Novel Brain Theranostics
- Affiliations
-
- 1Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea. dsl@snu.ac.kr
- 2Department of MolecularMedicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Republic of Korea.
- KMID: 2431978
- DOI: http://doi.org/10.1007/s13139-018-0550-9
Abstract
- Brain disease is one of the greatest threats to public health. Brain theranostics is recently taking shape, indicating the treatments of stroke, inflammatory brain disorders, psychiatric diseases, neurodevelopmental disease, and neurodegenerative disease. However, several factors, such as lack of endophenotype classification, blood-brain barrier (BBB), target determination, ignorance of biodistribution after administration, and complex intercellular communication between brain cells, make brain theranostics application difficult, especially when it comes to clinical application. So, a more thorough understanding of each aspect is needed. In this review, we focus on recent studies regarding the role of exosomes in intercellular communication of brain cells, therapeutic effect of graphene quantum dots, transcriptomics/epitranscriptomics approach for target selection, and in vitro/in vivo considerations.
