Arch Plast Surg.  2018 Nov;45(6):564-571. 10.5999/aps.2018.00605.

Application of a paste-type acellular dermal matrix for coverage of chronic ulcerative wounds

• Jeon M
• Kim SY

• KMID: 2427547
• DOI: http://doi.org/10.5999/aps.2018.00605

Abstract

BACKGROUND
Chronic wounds occur due to failure of the normal healing process, associated with a lack of deposition of cellular components and a suitable microenvironment such as the extracellular matrix (ECM). Acellular dermal matrix (ADM) is viewed as an ECM substitute, and a paste-type ADM has recently been introduced. We hypothesized that CGPaste, an injectable paste-type ADM, could serve as a scaffold and promote wound healing.
METHODS
We retrospectively studied seven patients in whom CGPaste was applied between 2017 and 2018, who had pressure ulcers, necrotizing fasciitis, diabetic foot ulcers, traumatic defects, and osteomyelitis. The goal of applying CGPaste was to achieve complete wound healing with re-epithelialization or growth of granulation tissue, depending upon the wound bed status. CGPaste was injected based on the wound size along with the application of a dressing.
RESULTS
Four of the seven patients showed granulation tissue on their wound bed, while the other three patients had a bony wound bed. The mean wound area was 453.57 mm2 and the depth was 10.71 mm. Wound healing occurred in five of the seven patients (71.43%). The mean duration of complete healing was 2.4 weeks. Two patients showed failure due to paste absorption (29.57%); these patients had wound beds comprising bone with relatively large and deep wounds (40×30 and 30×20 mm2 in area and 15 and 10 mm in depth).
CONCLUSIONS
CGPaste is an effective option for coverage of small and deep chronic wounds for which a flap operation or skin grafting is unfeasible.

Keyword

Acellular dermis; Ulcer; Wound healing

MeSH Terms

Absorption
Acellular Dermis*
Bandages
Diabetic Foot
Extracellular Matrix
Fasciitis, Necrotizing
Granulation Tissue
Humans
Osteomyelitis
Pressure Ulcer
Re-Epithelialization
Retrospective Studies
Skin Transplantation
Ulcer*
Wound Healing
Wounds and Injuries*