J Wound Manag Res.  2019 Mar;15(1):23-30. 10.22467/jwmr.2018.00535.

A Clinical Study of Micronized Acellular Dermal Matrix Collagen Paste Application with Negative Pressure Wound Therapy

• Ahn SK
• Choi HJ
• Lee JB
• Kim JH

• KMID: 2469757
• DOI: http://doi.org/10.22467/jwmr.2018.00535

Abstract

INTRODUCTION
Micronized cadaveric acellular dermal matrix (mADM) paste, which functions by filling vertical wound planes with acellular dermal matrix particles and gelatin suspension, is a novel option for the treatment of hard-to-heal wounds. We aimed to evaluate the clinical outcome of mADM paste used in conjunction with negative pressure wound therapy (NPWT) in the treatment of hard-to-heal wounds.
METHODS
This prospective clinical trial enrolled 20 patients with hard-to-heal wounds from January 2016 to January 2017. Wound healing was assessed at 1, 2, 3, and 4 weeks after treatment. Wound size and depth and patient satisfaction were recorded at each follow-up.
RESULTS
The area of the wound was measured in all study participants, which decreased from an average of 15.48±22.38 cm² at the start of the study to 8.97±17.73 cm² after 4 weeks, with a reduction rate of 59.10%±31.76% (P<0.0001). Two weeks into the study, there was a significant decline in the wound depth compared with the previous week.
CONCLUSION
mADM with NPWT provides effective wound healing. It is more comfortable for the patients and less time-consuming for the nursing staff; thus, this treatment deserves a prominent place in the care of patients with hard-toheal wounds.

Keyword

Negative-pressure wound therapy; CG Paste; Acellular dermal matrix; Pressure sore

MeSH Terms

Acellular Dermis*
Cadaver
Clinical Study*
Collagen*
Follow-Up Studies
Gelatin
Humans
Negative-Pressure Wound Therapy*
Nursing Staff
Patient Satisfaction
Pressure Ulcer
Prospective Studies
Wound Healing
Wounds and Injuries
Collagen
Gelatin