J Korean Med Sci.  2018 Nov;33(47):e300. 10.3346/jkms.2018.33.e300.

Psychiatric Manifestation in Patients with Parkinson's Disease

• Han JW
• Ahn YD
• Kim WS
• Shin CM
• Jeong SJ
• Song YS
• Bae YJ
• Kim JM

• KMID: 2426357
• DOI: http://doi.org/10.3346/jkms.2018.33.e300

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Although its major manifestation is motor symptoms, resulting from the loss of dopaminergic neurons in the substantia nigra, psychiatric symptoms, such as depression, anxiety, hallucination, delusion, apathy and anhedonia, impulsive and compulsive behaviors, and cognitive dysfunction, may also manifest in most patients with PD. Given that the quality of life "” and the need for institutionalization "” is so highly dependent on the psychiatric well-being of patients with PD, psychiatric symptoms are of high clinical significance. We reviewed the prevalence, risk factors, pathophysiology, and treatment of psychiatric symptoms to get a better understanding of PD for improved management.

Keyword

Parkinson's Disease; Psychiatry; Depression; Psychosis; Impulse Control Disorder; Dementia

MeSH Terms

Anhedonia
Anxiety
Apathy
Compulsive Behavior
Delusions
Dementia
Depression
Dopaminergic Neurons
Hallucinations
Humans
Institutionalization
Neurodegenerative Diseases
Parkinson Disease*
Prevalence
Psychotic Disorders
Quality of Life
Risk Factors
Substantia Nigra