Tuberc Respir Dis.  2002 Mar;52(3):207-218.

Antibiotic Resistance for Common Hospital Acquired-pneumonia Pathogens in the Intensive Care Unit of Newly Opened Hospital

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea. LEEJH1126@lycos.co.kr

Abstract

BACKGROUND: Intensive care units (ICUs) are generally considered epicenters of antibiotic resistance and the principal sources of multi-resistant bacteria outbreaks. The antibiotic resistance in newly opened intens ive care unit that has no microbial colonization on and around the devices was investigated.
METHODS
The authors analyzed the antibiotic resistance patterns for common hospital acquired-pneumonia pathogens in the ICUs(Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter spp.) at the newly opened ICU of Hanyang University Medical Center, Kuri Hospital during 6 years(1995-2000).
RESULTS
1) Regarding Staphylococcus aureus, the resistance rate to methicillin was 15% at 1995, 21% at 1996, 20% at 1997, 23% at 1998, 22% at 1999, 55% at 2000. 2) Regarding Pseudomonas aeruginosa, the resistance rate to 3rd cephalosporin was 50% at 1995, 50% at 1996, 78% at 1997, 40% at 1998, 77% at 1999, 39% at 2000. Imipenam was 0% at 1995, 27% at 1996, 65% at 1997, 12% at 1998, 16% at 1999, 12% at 2000. Ciprofloxacin was 0% at 1996, 56% at 1997, 36% at 1998, 57% at 1999, 58% at 2000. Tobramycin was 7% at 1995, 10% at 1996, 67% at 1997, 36% at 1998, 65% at 1999, 12% at 2000. Gentamycin was 14% at 1995, 36% at 1996, 67% at 1997, 36% at 1998, 65% at 1999, 12% at 2000. Amikacin was 14% at 1995, 30% at 1996, 61% at 1997, 16% at 1998, 39% at 1999, 18% at 2000. 3) Regarding Acinetobacter spp., the resistance rate to 3rd cephalosporin was 92% at 1996, 89% at 1997, 88% at 1998, 84% at 1999, 77% at 2000. Imipenem was 50% at 1996, 48% at 1997, 45% at 1998, 49% at 1999, 50% at 2000. Ciprofloxacin was 0% at 1996, 48% at 1997, 33% at 1998, 27% at 1999, 71% at 2000. Tobramycin was 67% at 1995, 100% at 1996, 93% at 1997, 95% at 1998, 89% at 1999, 77% at 2000. Gentamycin was 67% at 1995, 100% at 1996, 89% at 1997, 95% at 1998, 87% at 1999, 83% at 2000. Amikacin was 33% at 1995, 83% at 1996, 82% at 1997, 88% at 1998, 75% at 1999, 69% at 2000.
CONCLUSIONS
The S.aureus resistance to methicillin, the Pseudomonas aeruginosa resistance to ciprofloxacin, and the A cinetobacter spp. resistance to ciprofloxacin have rapidly increased during 6 years. There is a need to pay special attention when using the the antibiotics for the above pathogens. This data may be useful in antibiotic therapy in newly opened intensive care units.

Keyword

Antiboitic resistance; Intensive care unit; Newly opened hospital

MeSH Terms

Academic Medical Centers
Acinetobacter
Amikacin
Anti-Bacterial Agents
Bacteria
Ciprofloxacin
Colon
Disease Outbreaks
Drug Resistance, Microbial*
Gentamicins
Imipenem
Intensive Care Units*
Critical Care*
Methicillin
Pseudomonas aeruginosa
Staphylococcus aureus
Tobramycin
Amikacin
Anti-Bacterial Agents
Ciprofloxacin
Gentamicins
Imipenem
Methicillin
Tobramycin
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