Obstet Gynecol Sci.  2018 Mar;61(2):253-260. 10.5468/ogs.2018.61.2.253.

Serum visfatin levels in non-obese women with polycystic ovary syndrome and matched controls

• Kim JJ
• Choi YM
• Hong MA
• Kim MJ
• Chae SJ
• Kim SM
• Hwang KR
• Yoon SH
• Ku SY
• Suh CS
• Kim SH

• KMID: 2420180
• DOI: http://doi.org/10.5468/ogs.2018.61.2.253

Abstract

OBJECTIVE
The purpose of the current study was to compare the circulating levels of visfatin between women with polycystic ovary syndrome (PCOS) and those without PCOS and to assess the correlations between visfatin levels and various parameters.
METHODS
This case-control study recruited 74 PCOS patients and 74 age- and body mass index (BMI)-matched controls. Serum visfatin levels were evaluated using the enzyme-linked immunosorbent assay. Women with PCOS were divided into 2 subgroups based on the presence of clinical or biochemical hyperandrogenism. The possible differences in serum visfatin levels between the hyperandrogenic and non-hyperandrogenic groups were also assessed.
RESULTS
Visfatin levels in PCOS patients were similar to those in the controls. However, hyperandrogenic patients had significantly higher mean serum visfatin levels than those in non-hyperandrogenic patients (3.87 ng/mL; 95% confidence intervals [CIs], 3.09-4.85 in hyperandrogenic group vs. 2.69 ng/mL; 95% CIs, 2.06-3.52 in non-hyperandrogenic group; P=0.038). In women with PCOS, visfatin levels positively correlated with BMI (r=0.23; P=0.047) and the log free androgen index (FAI) (r=0.27; P=0.021) and negatively correlated with high-density lipoprotein (HDL) cholesterol levels (r=−0.37; P=0.025). Except for HDL cholesterol levels, these correlations were also observed in controls.
CONCLUSION
Visfatin levels in PCOS patients were similar to those in the controls. However, hyperandrogenic patients showed significantly higher serum visfatin levels than those of non-hyperandrogenic patients, and visfatin had a positive linear correlation with FAI in both PCOS patients and controls.

Keyword

Adipocytokine; Polycystic ovary syndrome; Nicotinamide phosphoribosyltransferase; Visfatin

MeSH Terms

Body Mass Index
Case-Control Studies
Cholesterol
Cholesterol, HDL
Enzyme-Linked Immunosorbent Assay
Female
Humans
Hyperandrogenism
Lipoproteins
Nicotinamide Phosphoribosyltransferase*
Polycystic Ovary Syndrome*
Cholesterol
Cholesterol, HDL
Lipoproteins
Nicotinamide Phosphoribosyltransferase

Figure

• 

  Fig. 1 Correlations between serum visfatin levels and various parameters in women with polycystic ovary syndrome (PCOS). BMI, body mass index; HDL, high-density lipoprotein; FAI, free androgen index.

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