Yonsei Med J.  2018 Jan;59(1):158-161. 10.3349/ymj.2018.59.1.158.

Life-Threatening Thrombocytopenia Following Intravenous Contrast Media Infusion

• Park M
• Kim M
• Park J
• Cho J

• KMID: 2418864
• DOI: http://doi.org/10.3349/ymj.2018.59.1.158

Abstract

Radiocontrast media-induced acute severe thrombocytopenia is a very rare complication and potentially life-threatening. Here, we report the case of a 63-year-old male patient with severe acute thrombocytopenia following first exposure to intravenous non-ionic contrast media without immediate allergic reactions. His platelet count dropped from 107000/µL to 2000/µL after six hours of radiocontrast infusion. After administration of corticosteroid and transfusion of platelet concentrates, the platelet count returned gradually to normal within 5 days. To the best of our knowledge, non-ionic contrast media-induced isolated acute severe thrombocytopenia following no signs or symptoms of immediate allergic reaction has never been described.

Keyword

Thrombocytopenia; contrast media; non-ionic; hypersensitivity

MeSH Terms

Acute Disease
Administration, Intravenous
Contrast Media/*administration & dosage/*adverse effects
Humans
Infusions, Intravenous
Male
Middle Aged
Platelet Count
Thrombocytopenia/*etiology
Contrast Media

Figure

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  Fig. 1 Changes in platelet level before and after development of acute thrombocytopenia.

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