Tissue Eng Regen Med.  2018 Aug;15(4):503-510. 10.1007/s13770-018-0142-x.

Wicking Property of Graft Material Enhanced Bone Regeneration in the Ovariectomized Rat Model

• Kim S
• Ahn T
• Han MH
• Bae C
• Oh DS

• KMID: 2418106
• DOI: http://doi.org/10.1007/s13770-018-0142-x

Abstract

BACKGROUND
Recruitment and homing cells into graft materials from host tissue is crucial for bone regeneration.
METHODS
Highly porous, multi-level structural, hydroxyapatite bone void filler (HA-BVF) have been investigated to restore critical size bone defects. The aim was to investigate a feasibility of bone regeneration of synthetic HA-BVF compared to commercial xenograft (Bio-Oss). HA-BVF of 0.7 mm in average diameter was prepared via template coating method. Groups of animals (n = 6) were divided into two with normal (Sham) or induced osteoporotic conditions (Ovx). Subsequently, subdivided into three treated with HA-BVF as an experiment or Bio-Oss as a positive control or no treatment as a negative control (defect). The new bone formation was analyzed by micro-CT and histology.
RESULTS
At 4 weeks post-surgery, new bone formation was initiated from all groups. At 8 weeks post-surgery, new bone formation in the HA-BVF groups was greater than Bio-Oss groups. Extraordinarily greater bone regeneration within the Ovx-HA group than Sham-Bio-Oss or Ovx-Bio-Oss group (p<0.05).
CONCLUSION
This study suggests that the immediate wicking property of HA-BVF from host tissue activates a natural healing cascade without the addition of exogeneous factors or progenitor cells. HA-BVF may be an effective alternative for repairing bone defects under both normal and osteoporotic bone conditions.

Keyword

Bone regeneration; Hydroxyapatite; Osteoporosis; Bone void filler

MeSH Terms

Animals
Bone Regeneration*
Capillary Action*
Durapatite
Heterografts
Methods
Models, Animal*
Osteogenesis
Osteoporosis
Rats*
Stem Cells
Transplants*
Durapatite