J Korean Acad Prosthodont.  2008 Aug;46(4):335-342.

Comparison on New Bone Formation Between Ovariectomized Rats and Normal Rats After Graft of Alloplastic bone material

Affiliations
  • 1Korea University Institute for Clinical Dental Research, Korea. guy-jw@hanmail.net

Abstract

PURPOSE
OF STUDY: To compare on bone formation between ovariectomized rats and normal rats after graft of alloplastic bone material. MATERIAL AND METHODS: Twenty female rats were used in this study. They were divided into two groups by each ten rats. One group was ovariectomized and grafted alloplastic bone material. Other group was non-ovariectomized and grafted alloplastic bone material. After a healing time of 4 weeks, the animals were sacrificed and decalcified preparations were routinely processed for histologic evaluations. RESULTS: Ovariectomy group was significantly lesser bone formation compared with non-ovariectomy group. CONCLUSIONS: Ovariectomy acts as a negative factor in new bone formation.

Keyword

Ovariectomy; New bone formation; Critical sized defect

MeSH Terms

Animals
Female
Humans
Osteogenesis
Ovariectomy
Rats
Transplants
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