J Cancer Prev.  2018 Jun;23(2):99-106. 10.15430/JCP.2018.23.2.99.

Leucrose, a Sucrose Isomer, Suppresses Hepatic Fat Accumulation by Regulating Hepatic Lipogenesis and Fat Oxidation in High-fat Diet-induced Obese Mice

• Lee J
• Kim E
• Kim Y
• Yoo SH

• KMID: 2417374
• DOI: http://doi.org/10.15430/JCP.2018.23.2.99

Abstract

Obesity is currently one of the most serious public health problems and it can lead to numerous metabolic diseases. Leucrose, d-glucopyranosyl-α-(1-5)-d-fructopyranose, is an isoform of sucrose and it is naturally found in pollen and honey. The aim of this study was to investigate the effect of leucrose on metabolic changes induced by a high-fat diet (HFD) that lead to obesity. C57BL/6 mice were fed a 60% HFD or a HFD with 25% (L25) or 50% (L50) of its total sucrose content replaced with leucrose for 12 weeks. Leucrose supplementation improved fasting blood glucose levels and hepatic triglyceride content. In addition, leucrose supplementation reduced mRNA levels of lipogenesis-related genes, including peroxisome proliferator-activated receptor γ, sterol regulatory element binding protein 1C, and fatty acid synthase in HFD mice. Conversely, mRNA levels of β oxidation-related genes, such as carnitine palmitoyltransferase 1A and acyl CoA oxidase, returned to control levels with leucrose supplementation. Taken together, these results demonstrated the therapeutic potential of leucrose to prevent metabolic abnormalities by mediating regulation of plasma glucose level and hepatic triglyceride accumulation.

Keyword

Leucrose; High fat diet; Lipogenesis; Liver

MeSH Terms

Acyl-CoA Oxidase
Animals
Blood Glucose
Carnitine O-Palmitoyltransferase
Diet, High-Fat
Fasting
Honey
Lipogenesis*
Liver
Metabolic Diseases
Mice
Mice, Obese*
Negotiating
Obesity
Peroxisomes
Pollen
Public Health
RNA, Messenger
Sterol Regulatory Element Binding Protein 1
Sucrose*
Triglycerides
Acyl-CoA Oxidase
Blood Glucose
Carnitine O-Palmitoyltransferase
RNA, Messenger
Sterol Regulatory Element Binding Protein 1
Sucrose