Immune Netw.
2018 Jun;18(3):e20. 10.4110/in.2018.18.e20.
Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis
- Affiliations
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- 1Division of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea. bestmd2000@amc.seoul.kr
- 2Department of Biomedical Science and Technology, Konkuk University, Seoul 05066, Korea.
- 3Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea. ejchang@amc.seoul.kr
- KMID: 2414554
- DOI: http://doi.org/10.4110/in.2018.18.e20
Abstract
- IL-32 acts as a pro-inflammatory cytokine by inducing the synthesis of inflammatory molecules as well as promoting the morphological changes involved in the transformation of monocytes into osteoclasts (OCs). Evaluation of the functions of IL-32 has mainly focused on its inflammatory properties, such as involvement in the pathogenesis of various autoimmune diseases. Recently, IL-32 was shown to be involved in bone metabolism, in which it promotes the differentiation and activation of OCs and plays a key role in bone resorption in inflammatory conditions. IL-32γ also regulates bone formation in conditions such as ankylosing spondylitis and osteoporosis. In this review, we summarize the results of recent studies on the role of IL-32γ in bone metabolism in inflammatory arthritis.
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