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Osteoclasts: Crucial in Rheumatoid Arthritis

Jeong WJ, Kim HJ

Osteoclasts are a major component of bone metabolism in physiologic condition and in rheumatoid arthritis (RA). RA is a chronic, autoimmune, inflammatory disease primarily affecting the joints. Joint inflammation leads...
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Regulation of Osteoclast Differentiation: Identification of osteoclast and macrophage fusion protein; DC-STAMP

Miyamoto T

Osteoclasts are bone-resorbing multinuclear cells derived from hematopoietic stem cells or monocyte/ macrophage lineage cells. Recent identification of RANK/RANKL has provided new insights into the osteoclast differentiation pathway, enabling us...
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Factors and Mechanisms Involved in the Coupling from Bone Resorption to Formation: How Osteoclasts Talk to Osteoblasts

Ikeda K, Takeshita

Bone remodeling is the fundamental means by which the quality as well as quantity of the skeleton is maintained throughout adult life. When bone remodeling goes awry, a metabolic bone...
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The Effect of Substance P on Osteoclastogenesis and Osteoclastic Bone Resorption in vitro

Sohn SJ

  • KMID: 2276045
  • Korean J Otolaryngol-Head Neck Surg.
  • 2003 Oct;46(10):822-826.
BACKGROUND AND OBJECTIVES: Osteoclasts are the principal cell of bone resorption playing a major role in focal bone erosion associated with cholesteatoma. This study was conducted in order to investigate...
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A histological and histochemical study on the periodontal tissue reaction during experimental tooth movement in the rat

Lim JH

  • KMID: 2271405
  • Korean J Orthod.
  • 1976 Dec;6(1):33-38.
For the purpose of evaluating the response of the periodontal tissue in relation to the experimental tooth movement, orthodontic force was applied to 15 female rats. The animals were investigated...
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Effects of bisphosphonate and indomethacin on alveolar bone remodeling in rats

Cho MS, Kim JC

  • KMID: 2037989
  • Korean J Orthod.
  • 1996 Apr;26(2):163-174.
The purpose of this study was to examine the effects of bisphosphonate and indomethacin, blockers of bone resorption with different mechanisms, on alveolar bone remodeling. Male rats were divided into...
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Odontogenic Ameloblast-Associated Protein (Odam) Plays Crucial Roles in Osteoclast Differentiation via Control of Actin Ring Formation

Lee HK, Park JC

PURPOSE: In osteoclast differentiation, actin-rich membrane protrusions play a crucial role in cell adhesion. Odontogenic ameloblast-associated protein (Odam) contributes to cell adhesion by inducing actin rearrangement. Odam-mediated RhoA activity may...
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Pathobiology of Paget's Disease of Bone

Galson DL, Roodman GD

Paget's disease of bone is characterized by highly localized areas of increased bone resorption accompanied by exuberant, but aberrant new bone formation with the primary cellular abnormality in osteoclasts. Paget's...
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Trichostatin A-mediated upregulation of p21

Yi T, Baek JH, Kim HJ, Choi MH, Seo SB, Ryoo HM, Kim GS, Woo KM

  • KMID: 1094662
  • Exp Mol Med.
  • 2007 Apr;39(2):213-221.
Histone deacetylase inhibitors (HDIs), a new class of anti-cancer agents, have been reported to suppress formation of osteoclast precursors and their fusion into multinucleated cells. However, little is known about...
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Effects on osteoclast in periodontal ligament space by denerveation of inferior alveolar nerve in young and adult rats

Park KD, Sung JH, Bae YC, Kyung HM

  • KMID: 2400560
  • Korean J Orthod.
  • 2004 Dec;34(6):506-513.
Osteoclast action is necessary for alveolar bone remodeling in orthodontic tooth movement. The nervous system has also been reported to be associated with bone remodeling. This study was aimed to...
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Effects of Bisphosphonate on the Tooth and Alveolar Bone Growth in Rats

Kim HJ, Kim MS, Lee MR, Jung JY, Kim WJ, Kim SH, Lee EJ

  • KMID: 2071896
  • Korean J Phys Anthropol.
  • 2005 Jun;18(2):149-157.
Eruptive movement of the tooth germ accompanies the resorption and formation of the surrounding alveolar bone. Bisphosphonate has effects on osteoclasts to inhibit bone resorption, being currently used for the...
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Biological characteristics of osteoporosis drugs: the effect of osteoblast–osteoclast coupling

Kim SJ, Moon SJ, Seo JT

Osteoporosis is a common disease characterized by bone mass reduction, leading to an increased risk of bone fracture, and it is caused by an imbalance of osteoblastic bone formation and...
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Signaling Pathways in Osteoclast Differentiation

Kim JH, Kim N

Osteoclasts are multinucleated cells of hematopoietic origin that are responsible for the degradation of old bone matrix. Osteoclast differentiation and activity are controlled by two essential cytokines, macrophage colony-stimulating factor...
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An electron microscopic study on the alveolar bone remodelling in pressure zones of rat molar periodontium associated with orthodontic tooth movement

Soun YS, Lee KS

  • KMID: 2271295
  • Korean J Orthod.
  • 1989 Jul;19(2):37-55.
The tissue reactions concerned in alveolar bone remodelling at the pressure zones of rat molar periodontium associated with the application of force (15 gm) to the maxillary first molar teeth...
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Gorham's Syndrome: A Case Report

Son MH, Kim DJ, Park JG, Choi JS, Lee YG

Gorham's syndrome is a rare disorder involing a proliferation of vascular channels associated with extensive loss of bony matrix. It starts in bone, but it may secondarily involve soft tissue...
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Identification of Alternatively Spliced Forms of human OSCAR in Osteoclasts

Kim N, Park HY, Kim HD

OBJECTIVES: Osteoclasts are multinucleated giant cells which can resorb bone and differentiated from hematopoietic cells. We have previously reported murine osteoclast-associated receptor (OSCAR) may be an important bone-specific regulator of...
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Osteoprotegerin is present on the membrane of osteoclasts isolated from mouse long bones

Woo KM, Choi Y, Ko SH, Ko JS, Oh KO, Kim KK

  • KMID: 755206
  • Exp Mol Med.
  • 2002 Nov;34(5):347-352.
Osteoprotegerin (OPG), a member of the tumor necrosis factor receptor superfamily, is known to inhibit osteoclastogenesis by acting as a soluble decoy receptor for the receptor activator of NF-kB ligand...
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A Case of Giant Cell Tumor of Tendon Sheath

No authors listed

  • KMID: 1930780
  • Korean J Dermatol.
  • 1994 Oct;32(5):939-943.
We report a case of the giant cell tumor of tendon sheath involving the finger in a 45-year-old woman who presented with asymptomatic, firm, 1x1 cm sized nodule on the...
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An initial histologic study on molar intrusion of cat with the usage of permanent magnet

Kim SC, Ryu YK

  • KMID: 2271498
  • Korean J Orthod.
  • 1990 Mar;20(1):169-179.
Utilizing the repelling force of permanent magnet of find out weather it shows the findings of molar intrusion histologically and compares the result with the resin bite plane. As for...
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The bone changes of the midpalatal suture after rapid palatal expansion in young adult dogs

Park CW, Yoon YJ, Kim KW

  • KMID: 2271749
  • Korean J Orthod.
  • 1997 Jun;27(3):389-399.
Rapid palatal expansion(RPE) is a method of inducing the new bone formation in the palate by separation of the midpalatal suture, which can be done conveniently by placing heavy force...
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