Chonnam Med J.  2016 Jan;52(1):12-17. 10.4068/cmj.2016.52.1.12.

Signaling Pathways in Osteoclast Differentiation

Affiliations
  • 1Department of Pharmacology, Chonnam National University Medical School, Gwangju, Korea. nacksung@jnu.ac.kr

Abstract

Osteoclasts are multinucleated cells of hematopoietic origin that are responsible for the degradation of old bone matrix. Osteoclast differentiation and activity are controlled by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and the receptor activator of nuclear factor-kappaB ligand (RANKL). M-CSF and RANKL bind to their respective receptors c-Fms and RANK to stimulate osteoclast differentiation through regulation of delicate signaling systems. Here, we summarize the critical or essential signaling pathways for osteoclast differentiation including M-CSF-c-Fms signaling, RANKL-RANK signaling, and costimulatory signaling for RANK.

Keyword

Bone and bones; Macrophage colony-stimulating factor; RANK ligand; Osteoclasts; Signal transduction

MeSH Terms

Bone and Bones
Bone Matrix
Cytokines
Macrophage Colony-Stimulating Factor
Osteoclasts*
RANK Ligand
Signal Transduction
Cytokines
Macrophage Colony-Stimulating Factor
RANK Ligand
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