Mycobiology.
2008 Jun;36(2):106-109.
Anti-tumor Effects of Exo- and Endo-biopolymers Produced from Submerged Cultures of Three Different Mushrooms
- Affiliations
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- 1Department of Biotechnology, Daegu University, Gyeongbuk, Gyeongsan 712-714, Korea. chsong@daegu.ac.kr
- 2Research Center for Processing & Application of Agricultural Products, Daegu University, Gyeongbuk, Gyeongsan 712-714, Korea.
Abstract
- The anti-tumor effects of exo- (EX) and endo-biopolymers (EN) produced from submerged mycelial cultures of Ganoderma applanatum (GA), Collybia confluens (CC), and Pleurotus eryngii (PE) were studied using Sarcoma 180 bearing mice. Solid tumor growth was inhibited most effectively when 40 mg/kg body weight (BW) of GA-EX or PE-EN was administered to the intraperitoneal (i.p.) cavity of BALB/c mice. The spleen and liver indexes were increased in mice following i.p. administration of GA-EX and PE-EN fractions. GA-EX and PE-EN reduced the tumor formation by 30.7% and 29.4%, respectively. GA-EX and PE-EN increased the natural killer (NK) cell activity of splenocytes by 41.3% and 28.9%, respectively.
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