Immune Netw.  2002 Jun;2(2):115-124. 10.4110/in.2002.2.2.115.

Immunomodulating and Antitumor Activities of Exo-secretion from Phellinus linteus

Affiliations
  • 1Korea Testing and Research Institute for Chemical Industry, Korea. mvirus@kotric.co.kr
  • 2Department of Microbiology, Dankook University, Korea.
  • 3Department of Clinical Pathology, Shinheung College, Korea.
  • 4National Cancer Center, Korea.

Abstract

BACKGROUND: The chemical characteristics of the exo-secretion from Phellinus linteus (referred to as exo-secretion) including the compositions of amino acids and monosaccharides were investigated. In addition, cytotoxicity of the exo-secretion on 5 tumor cell lines derived from human cancers and its antitumor activity against ascitic sarcoma-180 cells were examined.
METHODS
The antitumor activity of exo-secretion from Phellinus linteus was determined by measuring parameters including tumor weight, life span of mice, chemotatic activity of leukocytes, counts of immune cells, and activity of cytokines.
RESULTS
The exo-secretion from Phellinus linteus showed no direct cytotoxicity to the five tumor cell lines tested, but it had a strong antitumor activity against sarcoma-180 cells in ICR mice as measured by tumor weight and life span of mice. The exo-secretion stimulated the chemotaxis of leukocytes and production of immune cells and cytokines.
CONCLUSION
These results suggest that the exo- secretion from Phellinus linteus do not act as a direct cytotoxic substance to cancer cells but as an immunomodulator.

Keyword

Phellinus linteus; antitumor; cytotoxicity; cytokines; immunomodulator

MeSH Terms

Amino Acids
Animals
Cell Line, Tumor
Chemotaxis
Cytokines
Humans
Leukocytes
Mice
Mice, Inbred ICR
Monosaccharides
Tumor Burden
Amino Acids
Cytokines
Monosaccharides
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