Mycobiology.  2008 Mar;36(1):45-49. 10.4489/MYCO.2008.36.1.045.

Hypoglycemic Effects of Exo-biopolymers Produced by Five Different Medicinal Mushrooms in STZ-induced Diabetic Rats

• Yang BK
• Kim GN
• Jeong YT
• Jeong H
• Mehta P
• Song CH

• KMID: 2052887
• DOI: http://doi.org/10.4489/MYCO.2008.36.1.045

Abstract

Hypoglycemic effects of exo-biopolymers (EBP) produced by submerged mycelial cultures of Coriolus versicolor, Cordyceps sinensis, Paecilomyces japonica, Armillariella mellea, and Fomes fomentarius were investigated in streptozotocin (STZ)-induced diabetic rats. The rats from each experimental group were orally administered with EBPs (100 mg/kg BW) daily for 2 weeks. Though the hypoglycemic effect was achieved in all the cases, however, C. versicolor EBP proved as the most potent one. The administration of the C. versicolor EBP substantially reduced (29.9%) the plasma glucose level as compared to the saline administered group (control). It also reduced the plasma total cholesterol (TC), triglyceride (TG), aspartate aminotransferase (AST) and, alanine aminotransferase (ALT) levels by 9.22, 23.83, 16.93, and 27.31%, respectively. The sugar and amino acid compositions of this EBP were also analyzed in detail.

Keyword

Exo-biopolymer; Hypoglycemic effect; Mushrooms

MeSH Terms

Agaricales
Alanine Transaminase
Animals
Aspartate Aminotransferases
Cholesterol
Cordyceps
Coriolaceae
Glucose
Hypoglycemic Agents
Paecilomyces
Plasma
Rats
Streptozocin
Alanine Transaminase
Aspartate Aminotransferases
Cholesterol
Glucose
Hypoglycemic Agents
Streptozocin