Nat Prod Sci.  2015 Mar;21(1):6-13. 10.0000/nps.2015.21.1.6.

Phytochemical Constituents from the Aerial Part of Ducrosia ismaelis Asch

• Morgan AM
• Kim JH
• Lee HW
• Lee SH
• Lim CH
• Jang HD
• Kim YH

• KMID: 2409592
• DOI: http://doi.org/10.0000/nps.2015.21.1.6

Abstract

Phytochemical investigation of the aerial components of Ducrosia ismaelis Asch. led to the isolation of six known compounds, psoralen (1), isopsoralen (2), cnidioside A (3), (-)-syringaresinol-O-beta-D-glucopyranoside (4), (E)-plicatin B (5), trilinolein (6). The chemical structures of these compounds were elucidated from spectroscopic data and by comparison of these data with previously published results. The antioxidant, anti-osteoporotic and cardiovascular related activities of the isolated compounds were assessed using oxygen radical absorbance capacity (ORAC), reducing capacity, tartrate-resistant acid phosphatase (TRAP), and soluble epoxide hydrolase (sEH) inhibitory activity assays. Compounds (3-5) showed potent peroxyl radical-scavenging capacities with ORAC values of 11.06 +/- 0.39, 7.98 +/- 0.10, and 13.99 +/- 0.06 Trolox equivalent (TE) at concentrations of 10 microM, respectively. Only compounds 4 and 5 was able to significantly reduce Cu2+ ions, with a reduction value of 9.06 +/- 0.32 and 4.61 +/- 0.00 microM Trolox Equivalent (TE) at a concentration of 10 microM. Compound 5 at 10 microM exhibited a potent inhibitory effect on osteoclastic TRAP activity with a TRAP value of 86.05 +/- 6.55% of the control. Compounds 1, 3 and 5 potently inhibited sEH activity with IC50 values of 41.6 4.9, 16.0 1.1, and 49.0 5.7 microM, respectively.

Keyword

Ducrosia ismaelis; Apiaceae; ORAC; Reducing capacity; TRAP; Soluble epoxide hydrolase

MeSH Terms

Acid Phosphatase
Apiaceae
Ficusin
Inhibitory Concentration 50
Ions
Osteoclasts
Oxygen
Acid Phosphatase
Ficusin
Ions
Oxygen