Nat Prod Sci.  2020 Mar;26(1):90-96. 10.20307/nps.2020.26.1.90.

Chemical Constituents from the Aerial Parts of Artemisia capillaris Thunb. and Their Anti-allergic and Anti-inflammatory Effects

• Nguyen TT
• Vu TO
• Cao TQ
• Min BS
• Kim JA

• KMID: 2503931
• DOI: http://doi.org/10.20307/nps.2020.26.1.90

Abstract

Artemisia capillaris Thunb. (Compositae) is a traditional medicinal plant with various pharmacological activities. To elucidate new anti-allergic and anti-inflammatory constituents, the aerial parts of A. capillaries were investigated to afford a new compound, (6E,8E)-6-methylundeca-6,8-diene-2,5,10-trione (17) together with 19 known compounds (1 - 16, 18 - 20). The structures of these compounds were determined by extensive spectroscopic analyses including 1D, 2D NMR, HREIMS, and optical rotation [α]D. The absolute configuration of compound 2 was determined to be S form for the first time. All isolates (1 - 20) were tested their inhibitory effects on interleukin 2 (IL-2) expression in T cells and NO production in lipopolysaccharide (LPS)-stimulated RAW246.7. Among them, compounds 10, 11, 19, and 20 reduced IL-2 expression in a dose-dependent manner. In addition, compound 10 also inhibited NO production with an IC50 value of 37.3 ± 0.4 μM.

Keyword

Artemisia capillaris Thunb.; (6E,8E)-6-methylundeca-6,8-diene-2,5,10-trione; anti-allergic; antiinflammatory; IL-2; NO inhibition