Nat Prod Sci.  2018 Jun;24(2):132-138. 10.20307/nps.2018.24.2.132.

Phytochemical Constituents of Capsella bursa-pastoris and Their Anti-inflammatory Activity

• Cha JM
• Kim DH
• Lee TH
• Subedi L
• Kim SY
• Lee KR

• KMID: 2416075
• DOI: http://doi.org/10.20307/nps.2018.24.2.132

Abstract

Phytochemical investigation of 80% MeOH extract of the aerial parts of Capsella bursa-pastoris yielded fourteen compounds (1 - 14). The structures of the compounds were elucidated by spectroscopic methods to be methyl-1-thio-β-D-glucopyranosyl disulfide (1), 10-methylsulphinyl-decanenitrile (2), 11-methyl-sulphinyl-undecanenitrile (3), 1-O-(lauroyl)glycerol (4), phytene-1, 2-diol (5), (3S,5R,6S,7E)-5,6-epoxy-3-hydroxy-7-megastigmen-9-one (6), loliolide (7), β-sitosterol (8), 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1-propanone (9), 1-feruloyl-β-D-glucopyranoside (10), pinoresinol-4"²-O-β-D-glucopyranoside (11), luteolin (12), quercetin-3-O-β-D-glucopyranoside (13), and luteolin 6-C-β-glucopyranoside (14). Although compound 1 was reported as synthetic compound, 1 was first isolated from natural source. NMR spectral data assignments of 1, 2 and 3 were reported for the first time, and compounds 1 - 14 were for the first time reported from this plant source. The anti-inflammatory effects of 1 - 14 were evaluated in lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cells. Compounds 12 exhibited strong inhibitory effects on nitric oxide production in LPS-activated BV-2 cells with IC50 values of 9.70 µM.

Keyword

Capsella bursa-pastoris; Cruciferae; Sulfur compound

MeSH Terms

Brassicaceae
Capsella*
Inhibitory Concentration 50
Luteolin
Microglia
Nitric Oxide
Plants
Luteolin
Nitric Oxide

Figure

• 

  Fig. 1. The structures of 1 – 14 isolated from C. bursa-pastoris.

Reference

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