Nat Prod Sci.  2015 Jun;21(2):71-75. 10.0000/nps.2015.21.2.71.

Chemical Constituents from the Aerial Parts of Bupleurum falcatum L. and Biological Evidences

• Tung NH
• Uto T
• Morinaga O
• Shoyama Y

• KMID: 2312875
• DOI: http://doi.org/10.0000/nps.2015.21.2.71

Abstract

In this study, phytochemical investigation on the aerial parts of Bupleurum falcatum resulted in the isolation of fourteen compounds including three quinic acid derivatives (1 - 3), five flavonoids (4 - 8), three monoterpene glycosides (9 - 11), and three saikosaponins (12 - 14). Compound 1 was first isolated from nature and unambiguously determined to be 3-O-feruloyl 5-O-caffeoylquinic acid on the basis of the extensive spectroscopic evidence. Biological testing revealed that saikosaponin A (12) and saikosaponin D (13) showed moderate antiproliferative effects on HL-60 and HepG2 cancer cell lines.

Keyword

Bupleurum falcatum; Umbellifeae; Quinic acid; Saikosaponin; Anti-proliferative activity

MeSH Terms

Bupleurum*
Cell Line
Flavonoids
Glycosides
Quinic Acid
Flavonoids
Glycosides
Quinic Acid