Kidney Res Clin Pract.
2018 Mar;37(1):49-58. 10.23876/j.krcp.2018.37.1.49.
Weight loss has an additive effect on the proteinuria reduction of angiotensin II receptor blockers in hypertensive patients with chronic kidney disease
- Affiliations
-
- 1Department of Internal Medicine, Korea University Medical Center Guro Hospital, Seoul, Korea.
- 2Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
- 3Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
- 4Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Korea.
- 5Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea.
- 6Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
- 7Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.
- 8Research Institute of Salt and Health, Seoul, Korea.
- 9Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. mednep@snubh.org
- KMID: 2409374
- DOI: http://doi.org/10.23876/j.krcp.2018.37.1.49
Abstract
- BACKGROUND
Weight reduction is a lifestyle intervention that has been introduced for prevention and management of chronic kidney disease (CKD). We investigate the additive anti-proteinuric effect of weight reduction on the usage of angiotensin II receptor blockers (ARBs) and its potential mechanisms in hypertensive CKD patients.
METHODS
This study is a subanalysis of data from an open-label, randomized, controlled clinical trial. Among the 235 participants, 227 were assigned to subgroups according to changes in body weight.
RESULTS
Fifty-eight participants (25.6%) were assigned to group 1 (≥1.5% decrease in body weight after 16 weeks), 32 participants (14.1%) were assigned to group 2 (1.5-0.1% decrease in body weight), and 136 participants (59.9%) were assigned to group 3 (≥ 0.0% increase in body weight). Characteristics at enrollment were not different among the three groups, but mean differences in weight and percent changes in urinary sodium excretion over the period were statistically different (P < 0.001 and P = 0.017). Over the study period, unintentional weight loss independently increased the probability of reduced albuminuria (group 1, relative risk 6.234, 95% confidence interval 1.913-20.315, P = 0.002). Among urinary cytokines, only podocalyxin level decreased significantly in participants who lost weight (P = 0.013).
CONCLUSION
We observed that weight loss had an additive effect on the anti-proteinuric effects of ARBs in nondiabetic hypertensive CKD patients, although it was minimal. An additive effect was shown in both obese and non-obese participants, and its possible mechanism is related to reduction of podocyte damage.
Keyword
MeSH Terms
-
Albuminuria
Angiotensin II*
Angiotensin Receptor Antagonists*
Angiotensins*
Body Weight
Cytokines
Humans
Hypertension
Life Style
Podocytes
Proteinuria*
Receptors, Angiotensin*
Renal Insufficiency, Chronic*
Sodium
Weight Loss*
Angiotensin II
Angiotensin Receptor Antagonists
Angiotensins
Cytokines
Receptors, Angiotensin
Sodium
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